Antibodies against infectious diseases

Patent metadata

Field	Value
Publication number	US-10766951-B2
Application number	US-201615563614-A
Country	US
Kind code	B2
Filing date	Apr 1, 2016
Priority date	Apr 1, 2015
Publication date	Sep 8, 2020
Grant date	Sep 8, 2020

Abstract

Anti-CaENO1 antibodies and humanized antibodies are provided as an effective diagnostic agent or a therapeutic treatment against infections caused by Candida spp., preferably Candida albicans, Candida tropicalis, fluconazole resistance Candida spp., Streptococcus, Staphylococcus.

First claim

What is claimed is:

1. An isolated anti-CaENO1 antibody or an antigen-binding portion thereof, comprising a light chain complementarity determining region 1 (L-CDR1) of SEQ ID NO:5; a light chain CDR2 (L-CDR2) of SEQ ID NO:6; and a light chain CDR3 (L-CDR3) of SEQ ID NO:7; and a heavy chain CDR1 (H-CDR1) of SEQ ID NO:8; a heavy chain CDR2 (H-CDR2) of SEQ ID NO:9; and a heavy chain CDR3 (H-CDR3) of SEQ ID NO:10; such that said isolated antibody or antigen-binding portion thereof binds to CaENO1.

2. The antibody of claim 1 , wherein the isolated anti-CaENO1 antibody is a monoclonal antibody, chimeric antibody or humanized antibody.

3. The antibody of claim 1 , wherein the light chain of the antibody comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:13 and 14; or wherein the heavy chain of the antibody comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 15 and 16.

4. The antibody of claim 1 , which is a humanized antibody comprising (i) a light chain having an amino acid sequence selected from the group consisting of SEQ ID NOs:13 and 14, and (ii) a heavy chain having an amino acid sequence selected from the group consisting of SEQ ID NOs:15 and 16.

5. The humanized antibody of claim 4 , which comprises:
(i) a light chain having an amino acid sequence of SEQ ID NO:13 and (ii) a heavy chain having an amino acid sequence of SEQ ID NO: 15 or
(iii) a light chain having an amino acid sequence of SEQ ID NO: 14 and (iv) a heavy chain having an amino acid sequence of SEQ ID NO: 16.

Assignees

• Univ Taipei Medical

Inventors

• Leu Sy-Jye
• Yang Yi-Yuan
• Lee Yu-Ching
• Su Ching-Hua
• Liu Ko-Jiunn
• Lo Hsiu-Jung
• Yang Yun-Liang

Classifications

• G01N33/56938

  Staphylococcus · CPC title

• C07K16/02

  from eggs · CPC title

• G01N33/573

  for enzymes or isoenzymes · CPC title

• C12N9/60

  from yeast · CPC title

• G01N33/56944

  Streptococcus · CPC title