Drug delivery device

Patent metadata

Field	Value
Publication number	US-10682474-B2
Application number	US-201615040372-A
Country	US
Kind code	B2
Filing date	Feb 10, 2016
Priority date	Nov 21, 2012
Publication date	Jun 16, 2020
Grant date	Jun 16, 2020

Abstract

A drug delivery device includes a blunt cannula and a reservoir. The blunt cannula has a cylindrical wall that defines an axial passage between a first end and a second end of the blunt cannula. The wall has at least a first tapered region at the first end to define an opening in fluid communication with the axial passage and adapted at the first end to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula. The reservoir is connected to the second end of the blunt cannula.

First claim

We claim:

1. A wearable on-body drug delivery device comprising:
a housing having an opening;
an adhesive layer attached to a surface of the housing for attaching the drug delivery device to a patient's skin;
a reservoir disposed in the housing and adapted to contain a drug product;
a first needle;
a cannula having a cylindrical wall that defines an axial passage between a first end and a second end of the cannula, the first end of the cannula being initially retracted within the housing and subsequently deployed through the opening in the housing for introduction into the patient's skin prior to delivery of the drug product to the patient, the cannula configured to be operably connected in fluid communication with the reservoir via the first needle to deliver the drug product to the patient; and
an introducer needle disposed in the cannula adapted for introducing the cannula into the patient's skin and subsequently withdrawing from the cannula prior to delivery of the drug product to the patient.

2. The drug delivery device of claim 1 , wherein the introducer needle extends beyond the first end of the cannula when introducing the cannula into the patient's skin.

3. The drug delivery device according to claim 1 , wherein the cannula has at least one side port formed in the wall of the cannula at the first end.

4. The drug delivery device according to claim 3 , wherein the at least one side port comprises a pair of side ports.

5. The drug delivery device according to claim 4 , wherein the pair of side ports are aligned with each other across the axial passage.

6. The drug delivery device according to claim 3 , wherein the at least one side port comprises a circular opening formed in the wall to permit flow transverse to the axial passage.

7. The drug delivery device according to claim 3 , wherein the at least one side port comprises an elongated slit formed in the wall to permit flow transverse to the axial passage.

8. The drug delivery device according to claim 3 , wherein the at least one side port comprises an elongated slot formed in the wall to permit flow transverse to the axial passage.

9. The drug delivery device according to claim 3 , wherein the first end of the cannula includes a first tapered region, and wherein the at least one side port is formed in the first end of the cannula distal from the first tapered region.

10. The drug delivery device according to claim 1 , wherein the first end of the cannula includes a first tapered region that comprises at least one bevel.

11. The drug delivery device according to claim 10 , wherein the first tapered region comprises only one bevel.

12. The drug delivery device according to claim 10 , wherein the first tapered region comprises two bevels intersecting each other.

13. The drug delivery device according to claim 10 , wherein the first tapered region comprises two negative or inverted bevels intersecting each other.

14. The drug delivery device according to claim 10 , wherein the first end of the cannula includes a pattern of openings disposed about an opening in the first tapered region.

15. The drug delivery device according to claim 14 , wherein the pattern of openings comprises a pattern of recesses into the wall.

16. The drug delivery device according to claim 1 , wherein the cannula has at least one external recessed region recessed toward the axial passage relative to adjoining surface regions.

17. The drug delivery device according to claim 16 , wherein the at least one external recessed region is defined by a pattern of ribs.

18. The drug delivery device according to claim 16 , wherein the at least one external recessed surface region is defined by a pattern of grooves.

19. The drug delivery device according to claim 1 , further comprising a barrel and a plunger disposed within the barrel to define the reservoir.

20. The drug delivery device according to claim 19 , further comprising a drive for moving the plunger through the barrel.

21. The drug delivery device of claim 1 , comprising a volume of the drug product disposed in the reservoir, the drug product comprising a monoclonal antibody (IgG) that binds human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9).

22. The drug delivery device of claim 1 , comprising a volume of the drug product disposed in the reservoir, the drug product comprising a granulocyte colony-stimulating factor (G-CSF).

23. A method of injecting a drug product into a patient, the method comprising:
attaching a housing of a wearable on-body drug delivery device to a patient's skin with an adhesive, the housing having an opening;
delivering in combination a cannula and an introducer needle into the patient's skin by moving the cannula and the introducer needle from an initial position within the housing to a deployed position where a first end of the cannula and a first end of the introducer needle extend through the opening in the housing, the cannula having a cylindrical wall that defines an axial passage between the first end and a second end of the cannula, the introducer needle disposed in the cannula and extending beyond the first end of the cannula;
withdrawing the introducer needle from the cannula after delivering the cannula to the patient's skin;
operably connecting, via a second needle, the second end of the cannula in fluid communication with a reservoir of the drug delivery device; and
delivering a volume of the drug product disposed in the reservoir into the patient.

24. The method of claim 23 , wherein delivering the drug product comprises moving a plunger through a barrel that comprises the reservoir, the plunger forcing the drug product through the cannula.

25. The method of claim 23 , wherein delivering the volume of the drug product disposed in the reservoir into the patient comprises delivering a monoclonal antibody (IgG) that binds human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) into the patient.

26. The method of claim 23 , wherein delivering the volume of the drug product disposed in the reservoir into the patient comprises delivering a granulocyte colony-stimulating factor (G-CSF) into the patient.

Assignees

• Amgen Inc

Inventors

• Ring Lawrence
• Mehta Dhairya
• Toy Stephanie
• Tamtoro Ferry
• Cairns Alexander Stuart
• Gibson Scott R

Classifications

• A61M5/3291 Primary

  Shafts with additional lateral openings · CPC title

• A61M5/14248 Primary

  of the skin patch type · CPC title

• A61K38/26

  Glucagons · CPC title

• A61M5/3134

  characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula · CPC title

• A61M25/0068

  Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure · CPC title