Oligosaccharide conjugates for targeting bacteria and uses related thereto
US-9821071-B2 · Nov 21, 2017 · US
Oligosaccharide conjugates for targeting bacteria and uses related thereto
US10646580B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10646580-B2 |
| Application number | US-201715801892-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 2, 2017 |
| Priority date | Jan 14, 2011 |
| Publication date | May 12, 2020 |
| Grant date | May 12, 2020 |
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- Title
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Abstract
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This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.
First claim
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What is claimed is: 1. An imaging method for a bacterial infection comprising a) administering a tracer molecule comprising a radionuclide or fluorescent molecule conjugated to maltodextrin to a subject; and b) determining whether the subject has a bacterial infection by scanning the subject and detecting a positron emitting or single photon emitting radionuclide or fluorescent molecule with an emission wavelength between 400 nm and 1200 nm. 2. The imaging method of claim 1 , further comprising the step of creating an image highlighting the location of the tracer molecule conjugated to maltodextrin in the subject. 3. The method of claim 1 , wherein the tracer molecule comprises a radionuclide, wherein the radionuclide is a positron-emitting radionuclide. 4. The method of claim 3 , wherein the positron-emitting radionuclide is selected from carbon-11, nitrogen-13, oxygen-15, fluorine-18, rubidium-82, and strontium-82. 5. The method of claim 1 , wherein the tracer molecule is a fluorescent molecule. 6. The method of claim 5 , wherein the fluorescent molecule is a fluorescent dye. 7. The method of claim 1 , wherein the maltodextrin comprises 2, 3, 4, 5, or 6 sugar oligomers. 8. The method of claim 1 , wherein the maltodextrin comprises greater than 2 glucose oligomers. 9. The method of claim 1 , wherein the tracer molecule comprises a positron-emitting radionuclide. 10. The method of claim 1 , wherein the tracer molecule conjugated to maltodextrin is 11. An imaging method for a bacterial infection comprising a) administering a tracer molecule comprising a radionuclide or fluorescent molecule conjugated to an oligosaccharide linked by an alpha 1, 4-covalent bond to a subject; and b) determining whether the subject has a bacterial infection by scanning the subject and detecting a positron emitting or single photon emitting radionuclide or fluorescent molecule with an emission wavelength between 400 nm and 1200 nm. 12. The method of claim 1 , wherein the tracer molecule comprises a radionuclide, wherein the radionuclide is a single photon emitting computed tomography radionuclide.
Assignees
Inventors
Classifications
Preparation of derivatives of starch (derivatives of amylose C08B33/00; derivatives of amylopectin C08B35/00) · CPC title
Methine dyes, e.g. cyanine dyes · CPC title
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title
Starch derivatives {, e.g. crosslinked derivatives} · CPC title
the fluorescent group being a small organic molecule · CPC title
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Frequently asked questions
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- What does patent US10646580B2 cover?
- This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosacchari…
- Who is the assignee on this patent?
- Univ Emory, Georgia Tech Res Inst, Univ Georgia State Res Found
- What technology area does this patent fall under?
- Primary CPC classification A61K47/61. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 12 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 5 related publications on this page (citations in our corpus or others sharing the same primary CPC).