Probes and methods of imaging a bacterial infection
US-9402925-B2 · Aug 2, 2016 · US
US9821071B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9821071-B2 |
| Application number | US-201414190928-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 26, 2014 |
| Priority date | Jan 14, 2011 |
| Publication date | Nov 21, 2017 |
| Grant date | Nov 21, 2017 |
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This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.
Opening claim text (preview).
What is claimed is: 1. A composition comprising a positron-emitting radionuclide conjugated to maltodextrin. 2. The composition of claim 1 , wherein the positron-emitting radionuclide is selected from carbon-11, nitrogen-13, oxygen-15, fluorine-18, rubidium-82, and strontium-82. 3. The composition of claim 1 , wherein the maltodextrin has greater than 2 glucose oligomers. 4. The composition of claim 1 , wherein the composition is
Macromolecular compounds, i.e. oligomers, polymers, dendrimers · CPC title
Preparation of derivatives of starch (derivatives of amylose C08B33/00; derivatives of amylopectin C08B35/00) · CPC title
Macromolecular compounds {, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules (peptides, proteins, polyamino acids A61K51/08; antibodies A61K51/10)} · CPC title
the fluorescent group being a small organic molecule · CPC title
the organic macromolecular compound being a polysaccharide or a derivative thereof · CPC title
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