Polymer particles

Patent metadata

Field	Value
Publication number	US-10632226-B2
Application number	US-201816237298-A
Country	US
Kind code	B2
Filing date	Dec 31, 2018
Priority date	Sep 28, 2016
Publication date	Apr 28, 2020
Grant date	Apr 28, 2020

Abstract

Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

First claim

We claim:

1. An embolic system including:
a syringe, a vial, or a combination thereof; and
polymer particles comprising at least one monomer including at least one functional group and at least one crosslinker having a structure

2. The embolic system of claim 1 , wherein the polymer particles have a diameter between about 40 μm and about 1,200 μm.

3. The embolic system of claim 1 , wherein the polymer particles have a diameter between about 75 μm and about 1,200 μm.

4. The embolic system of claim 1 , wherein the at least one functional group is acrylate, acrylamide, methacrylate, or methacrylamide.

5. The embolic system of claim 1 , wherein the at least one monomer includes an ionizable functional group.

6. The embolic system of claim 5 , wherein the ionizable functional group is basic.

7. The embolic system of claim 5 , wherein the ionizable functional group is acidic.

8. The embolic system of claim 1 , wherein the polymer particles include a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.

9. The embolic system of claim 1 , wherein the polymer particles are biodegradable.

10. The embolic system of claim 1 , wherein the polymer particles are substantially degraded within about 1 months of implantation.

11. The embolic system of claim 1 , wherein the at least one monomer is dimethylacrylamide.

12. The embolic system of claim 1 , wherein the at least one monomer is acrylamide.

13. A method of treatment, the method comprising:
delivering a solution including polymer particles through a delivery device to a treatment site,
wherein the polymer particles include at least one monomer including at least one functional group and at least one crosslinker having a structure

14. The method of claim 13 , wherein the polymer particles have a diameter between about 40 μm and about 1,200 μm.

15. The method of claim 13 , further comprising:
mixing a radiopaque contrast agent with the polymer particles.

16. The method of claim 13 , wherein the delivering is through a catheter, a microcatheter, or a needle.

17. The method of claim 13 , further comprising:
occluding blood flow using the polymer particles.

18. The method of claim 13 , wherein the polymer particles include a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.

19. The method of claim 13 , wherein the polymer particles are biodegradable.

20. The method of claim 19 , wherein the polymer particles are substantially degraded within about 6 months of implantation.

Assignees

• Terumo Corp

Inventors

• Hincapie Gloria
• Wu Xinping
• Wu Yue
• Cruise Gregory M

Classifications

• A61L26/0061

  Use of materials characterised by their function or physical properties · CPC title

• A61L26/0014

  obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61K31/4745 Primary

  condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines (yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48) · CPC title

• A61L31/048

  obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence) · CPC title

• A61L2300/204

  with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines · CPC title