Sodium channel modulators

Patent metadata

Field	Value
Publication number	US-10577308-B2
Application number	US-201615561674-A
Country	US
Kind code	B2
Filing date	Mar 24, 2016
Priority date	Mar 26, 2015
Publication date	Mar 3, 2020
Grant date	Mar 3, 2020

Abstract

The present disclosure relates generally to compounds having activity as voltage-gated sodium channel blockers and their use in the field of therapeutic treatment, including the therapy or management of conditions associated with excessive, unwanted, inadequate or otherwise undesirable sodium ion passage through cellular membranes via voltage-gated sodium channels. In some embodiments, the disclosure relates to aryloxy-substituted amines for use as sodium channel blockers or modulators. Methods for their manufacture and compositions containing the compounds are also disclosed.

First claim

The invention claimed is:

1. A compound selected from the group consisting of

or a pharmaceutically acceptable salt or solvate thereof.

2. A compound having the formula

or a pharmaceutically acceptable salt or solvate thereof.

3. A composition comprising the compound according to claim 1 , or a pharmaceutically acceptable salt or solvate thereof together with a pharmaceutically acceptable additive.

4. A method for preventing sodium ion influx into a cell by blocking or modulating the activity of one or more sodium channel sub-types, said method comprising contacting said cell with the compound according to claim 1 , or a pharmaceutically acceptable salt or solvate thereof.

5. A method for treating a disease or disorder which is mediated by sodium channel activity, in a subject in need thereof, comprising administering to said subject the compound according to claim 1 , or a pharmaceutically acceptable salt or solvate thereof, wherein the disease or disorder is an epileptic seizure.

Assignees

• The Florey Inst Of Neuroscience And Mental Health
• Univ Melbourne
• The Florey Inst

Inventors

• Williams Spencer John
• Jarrott Bevyn

Classifications

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• C07C311/37

  having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring · CPC title

• C07C255/58

  containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton · CPC title

• C07C311/16

  having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom · CPC title

• C07C217/58

  with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain · CPC title