Slip chip device and methods

Patent metadata

Field	Value
Publication number	US-10543485-B2
Application number	US-201615164788-A
Country	US
Kind code	B2
Filing date	May 25, 2016
Priority date	Mar 24, 2009
Publication date	Jan 28, 2020
Grant date	Jan 28, 2020

Abstract

A device is described having a first surface having a plurality of first areas and a second surface having a plurality of second areas. The first surface and the second surface are opposed to one another and can move relative to each other from at least a first position where none of the plurality of first areas, having a first substance, are exposed to plurality of second areas, having a second substance, to a second position. When in the second position, the plurality of first and second areas, and therefore the first and second substances, are exposed to one another. The device may further include a series of ducts in communication with a plurality of first second areas to allow for a substance to be disposed in, or upon, the plurality of second areas when in the first position.

First claim

The invention claimed is:

1. A reaction system for carrying out a reaction, the reaction system comprising:
a first part having a first surface;
a plurality of first areas located along a portion of the first surface; and
a second part having a second surface opposed to the first surface;
a plurality of second areas located along a portion of the second surface;
wherein at least one of the first surface of the first part and the second surface of the second part is configured to move relative to the other between a first position, wherein at least some of said plurality of first areas are exposed to at least some of said plurality of second areas so as to form a plurality of rows, each row comprising overlapping first areas and second areas in fluidic communication along said row;
a second position, wherein at least some of said plurality of first areas are exposed to at least some of said plurality of second areas so as to form a plurality of columns, each column comprising overlapping first areas and second areas in fluidic communication along said column;
wherein the first part and the second part are engaged with each other before and after the relative motion; and
wherein the first and second areas are configured to maintain at least one substance.

2. The reaction system of claim 1 , further comprising a plurality of channels in said first or second part, wherein said plurality of channels are in fluidic communication with said plurality of rows of overlapping first and second areas in said first position.

3. The reaction system of claim 2 , wherein said plurality of channels comprise inlet ducts or outlet ducts.

4. The reaction system of claim 1 , further comprising a plurality of channels in said first or second part, wherein said plurality of channels are in fluidic communication with said plurality of columns of overlapping first and second areas in said second position.

5. The reaction system of claim 4 , wherein said plurality of channels comprise inlet ducts or outlet ducts.

6. The reaction system of claim 1 , wherein said relative motion is linear, rotational, or a combination of both.

7. The reaction system of claim 1 , wherein said plurality of first areas are arranged in said first surface along rows extending parallel to one another.

8. The reaction system of claim 1 , wherein said plurality of second areas are arranged in said second surface along rows extending parallel to one another.

9. The reaction system of claim 1 , wherein said plurality of first areas or said plurality of second areas comprise ducts.

10. The reaction system of claim 1 , wherein at least one first area or second area comprises a capture element.

11. The reaction system of claim 10 , wherein the capture element is selected from the group consisting of antibodies, affinity-proteins, aptamers, beads, particles and biological cells.

12. The reaction system of claim 11 , wherein the capture element is surface-bound antibodies or bead-bound antibodies.

13. The reaction system of claim 1 , wherein the reaction comprises a synthetic reaction, a neutralization reaction, a decomposition reaction, a displacement reaction, a reduction-oxidation reaction, a precipitation, a crystallization, a combustion reaction, or a polymerization reaction.

14. The reaction system of claim 1 , wherein the reaction produces or consumes a gaseous product.

Assignees

• Univ Chicago

Inventors

• Ismagilov Rustem F
• Du Wenbin
• Li Liang
• Shen Feng
• Nichols Kevin Paul Flood
• Chen Delai
• Kreutz Jason Eugene

Classifications

• B01L3/502738 Primary

  characterised by integrated valves (throttle valves in microfluidic sample containers B01L3/502746) · CPC title

• B01L7/52

  with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples · CPC title

• B01L2300/0816

  Cards, e.g. flat sample carriers usually with flow in two horizontal directions · CPC title

• G01N21/78

  producing a change of colour · CPC title

• B01L2200/027

  for microfluidic devices · CPC title