Apoptosis signal-regulating kinase inhibitor

Patent metadata

Field	Value
Publication number	US-10508100-B2
Application number	US-201916246199-A
Country	US
Kind code	B2
Filing date	Jan 11, 2019
Priority date	Jan 27, 2012
Publication date	Dec 17, 2019
Grant date	Dec 17, 2019

Abstract

The present invention relates to a compound of formula (I):

The compound has apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis.

First claim

What is claimed is:

1. A method of preparing a compound of formula C:

or a salt thereof, comprising contacting a compound of formula B:

with propan-2-amine under conditions sufficient to form a compound of formula C.

2. The method of claim 1 , further comprising contacting a compound of formula A:

with dimethylformamide-dimethylacetal under conditions sufficient to form a compound of formula B.

Assignees

• Gilead Sciences Inc

Inventors

• Notte Gregory

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P31/12

  Antivirals · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title