Apoptosis signal-regulating kinase inhibitor

Patent metadata

Field	Value
Publication number	US-9873682-B2
Application number	US-201715491689-A
Country	US
Kind code	B2
Filing date	Apr 19, 2017
Priority date	Jan 27, 2012
Publication date	Jan 23, 2018
Grant date	Jan 23, 2018

Abstract

The present invention relates to a compound of formula (I):

The compound has apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis.

First claim

What is claimed is:

1. A tablet comprising a compound of formula (I):

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

2. The tablet of claim 1 , having 1 mg to 500 mg of the compound of formula (I).

3. The tablet of claim 1 , having 1 mg to 250 mg of the compound of formula (I).

4. A dosage unit comprising a compound of formula (I):

5. The dosage unit of claim 4 , having 1 mg to 500 mg of the compound of formula (I).

6. The dosage unit of claim 4 , having 1 mg to 250 mg of the compound of formula (I).

7. A method of treating liver fibrosis comprising administering to a patient in need thereof a tablet comprising a compound of formula (I):

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

8. The method of claim 7 , wherein the tablet is administered in combination with at least one other therapeutic agent.

9. The method of claim 8 , wherein the at least one other therapeutic agent is selected from the group consisting of an angiotensin converting enzyme inhibitor, an angiotensin II receptor blocker, an antihypertensive agent, an antibiotic agent, an analgesic agent, an antidepressant agent, or an antianxiety agent.

10. The method of claim 7 , wherein the tablet comprises 1 mg to 500 mg of the compound of formula (I).

11. The method of claim 7 , wherein the tablet comprises 1 mg to 250 mg of the compound of formula (I).

Assignees

• Gilead Sciences Inc

Inventors

• Notte Gregory

Classifications

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P31/12

  Antivirals · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title