Borate-glass biomaterials

Patent metadata

Field	Value
Publication number	US-10507263-B2
Application number	US-201515317746-A
Country	US
Kind code	B2
Filing date	Jun 9, 2015
Priority date	Jun 9, 2014
Publication date	Dec 17, 2019
Grant date	Dec 17, 2019

Abstract

Borate-glass biomaterials comprising: aNa2O. bCaO. cP2O5. dB2O3 wherein a is from about 1-40 wt %, b is from about 10-40 wt %, c is from about 1-40 wt %, and d is from about 35-80 wt %; and wherein the biomaterial has a surface area per mass of more than about 5 m2/g. Methods of making and uses of these biomaterials.

First claim

We claim:

1. A borate-glass biomaterial made by a sol-gel process comprising a composition having a B 2 O 3 component, a CaO component, and at least one other component selected from a P 2 O 5 component and a Na 2 O component, wherein:
the biomaterial is silica-free;
surface mineralization of the biomaterial, as measured by X-ray diffractometry (XRD), is initiated within 3 hours of contact with simulated body fluid; and
the biomaterial has a surface area per mass of more than about 5 m 2 /g.

2. The borate-glass biomaterial of claim 1 , wherein the composition comprises: aNa 2 O. bCaO. cP 2 O 5 . dB 2 O 3 , wherein a is from about 1-40 wt %, b is from about 10-40 wt %, c is from about 1-40 wt %, and d is from about 35-80 wt %.

3. The borate-glass biomaterial of claim 2 , wherein a is from about 15-30 wt %, b is from about 15-30 wt %, c is from about 3-7 wt %, and d is from about 35-65 wt %.

4. The borate-glass biomaterial of claim 2 , wherein a is from about 16-27 wt %, b is from about 16-27 wt %, c is from about 4-7 wt %, and d is from about 39-63 wt %.

5. The borate-glass biomaterial of claim 2 , wherein a is about 22.9 wt %, b is about 22.9 wt %, c is about 5.6 wt %, and d is about 48.6 wt %.

6. The borate-glass biomaterial of claim 2 , wherein a is about 20.7 wt %, b is about 20.7 wt %, c is about 5.1 wt %, and d is about 53.6 wt %.

7. The borate-glass biomaterial of claim 2 , wherein a is about 18.4 wt %, b is about 18.4 wt %, c is about 4.6 wt %, and d is about 58.6 wt %.

8. The borate-glass biomaterial of claim 2 , wherein a is about 16.2 wt %, b is about 16.2 wt %, c is about 4.1 wt %, and d is about 63.6 wt %.

9. The borate-glass biomaterial of claim 1 , wherein the composition comprises: xCaO. yP 2 O 5 . zB 2 O 3 , wherein x is from about 5-50 wt %, y is from about 5-50 wt %, and z is from about 35-75 wt %, or x is 10-50 wt %, y is 5-35 wt % and z is 38-80 wt %.

10. The borate-glass biomaterial of claim 1 , wherein the composition comprises: lNa 2 O. mCaO. nB 2 O 3 wherein 1 is from about 5-50 wt %, m is from about 1-50 wt %, and n is from about 40-80 wt %.

11. The borate-glass biomaterial of claim 1 , wherein the biomaterial has a surface area per mass of about 5-300 m 2 /g, 10-300 m 2 /g, 20-300 m 2 /g, 30-300 m 2 /g, 40-300 m 2 /g, 50-300 m 2 /g, 60-300 m 2 /g, 70-300 m 2 /g, 80-300 m 2 /g, 90-300 m 2 /g, 100-300 m 2 /g, 110-300 m 2 /g, 120-300 m 2 /g, 130-300 m 2 /g, 140-300 m 2 /g, 150-300 m 2 /g, 200-300 m 2 /g, 250-300 m 2 /g, 5-250 m 2 /g, 5-200 m 2 /g, 5-150 m 2 /g or 5-100 m 2 /g.

12. The borate-glass biomaterial of claim 1 , wherein the biomaterial has a pore volume per mass of biomaterial of about 0.1-3.0 cm 3 /g, 0.2-3.0 cm 3 /g, 0.3-3.0 cm 3 /g, 0.4-3.0 cm 3 /g, 0.5-3.0 cm 3 /g, 0.6-3.0 cm 3 /g, 0.7-3.0 cm 3 /g, 0.8-3.0 cm 3 /g, 0.9-3.0 cm 3 /g, 1.0-3.0 cm 3 /g, 0.1-2.5 cm 3 /g, 0.42-1.18 cm 3 /g or 0.1-2.0 cm 3 /g.

13. The borate-glass biomaterial of claim 1 , wherein the biomaterial can induce bone formation.

14. The borate-glass biomaterial of claim 1 , wherein the biomaterial is one of amorphous, crystalline or semi-crystalline.

15. The borate-glass biomaterial of claim 1 , wherein the biomaterial comprises at least one of: particles, fibrils, hollow spheres, solid spheres, monoliths, fibrous form or a porous sponge scaffold.

16. The borate-glass biomaterial of claim 1 , wherein the biomaterial comprises particles having a diameter of 0.2-1 μm, 5-2000 μm, 5-100 μm, or 25-75 μm.

17. The borate-glass biomaterial of claim 1 , further comprising a carrier.

18. The borate-glass biomaterial of claim 1 , wherein the biomaterial is coated on a bone implant surface.

19. The borate-glass biomaterial of claim 1 , for use in at least one of: mineralization, reducing dentine sensitivity, bone regeneration, wound healing, filling hard or soft tissue defects, as a coating on a bone implant, for enhancing the appearance of skin, or as a drug delivery vehicle.

20. The borate-glass biomaterial of claim 1 , wherein surface mineralization of the biomaterial, as measured by X-ray diffractometry (XRD), is initiated within 30 minutes of contact with simulated body fluid.

21. A method for making the borate-glass biomaterial of claim 1 , comprising combining a boron precursor and a calcium precursor, with at least one of a phosphate precursor and a sodium precursor to form a mixture; gelling the mixture to form a gel; drying the gel; and calcining the dried gel, wherein the boron precursor solution is selected from trimethyl borate B(OCH 3 ) 3 , triethyl borate B(C 2 H 5 O) 3 , tributyl borate B(CH 3 (CH 2 ) 3 O) 3 , Tri-tert-butyl borate (B 3 (CH 3 ) 3 CO) and boric acid, and wherein the calcium precursor is selected from calcium methoxyethoxide, Calcium nitrate tetrahydrate (Ca(NO 3 ) 2 4H 2 O), Calcium Chloride (CaCl 2 ), Calcium Ethoxide (Ca(C 2 H 5 O) 2 ), and Calcium methoxide (C 2 H 6 CaO 2 ).

22. The method of claim 21 , wherein the phosphate precursor is selected from triethyl phosphate, Trimethyl phosphate ((CH 3 ) 3 PO 4 ), Tributyl phosphate ((CH 3 CH 2 CH 2 CH 2 O) 3 PO), Dibutyl phosphate ((CH 3 CH 2 CH 2 CH 2 O) 2 P(O)OH), n-Butyl phosphate, mixture of monobutyl and dibutyl (C 8 H 19 O 4 P/C 4 H 11 O 4 P).

23. The method of claim 21 , wherein the sodium precursor is selected from Sodium methoxide (NaCH 3 O) in methanol and sodium hydroxide (NaOH).

24. The method of claim 21 , wherein the mixture comprises boric acid, anhydrous ethanol, triethyl phosphate, calcium methoxyethoxide, and sodium methoxide.

25. The method of claim 21 , wherein gelling the mixture comprises maintaining the solution at a temperature between about room temperature and about 60° C.

26. The method of claim 21 , wherein calcining the dry gel comprises heating the dry gel to between about 400-600° C., or about 100-400° C.

27. The method of claim 25 , wherein the temperature is about 37° C.

Assignees

• The Royal Institution For The Advancement Of Learning/Mcgill Univ

Inventors

• Nazhat Showan
• Lepry William Cole

Classifications

• A61L2420/06

  Coatings containing a mixture of two or more compounds · CPC title

• A61L2300/412

  Tissue-regenerating or healing or proliferative agents · CPC title

• A61L27/10 Primary

  Ceramics or glasses · CPC title

• A61K8/19

  containing inorganic ingredients · CPC title

• A61L27/54

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title