Wound care compositions comprising borate (B2O3) glass-based particles

Patent metadata

Field	Value
Publication number	US-9486554-B2
Application number	US-201314028148-A
Country	US
Kind code	B2
Filing date	Sep 16, 2013
Priority date	Jan 6, 2010
Publication date	Nov 8, 2016
Grant date	Nov 8, 2016

Abstract

Glass-based angiogenic particles of a biocompatible material which comprises 40 to about 80 wt% borate (B 2 O 3 ) intermixed into a carrier which is an ointment, cream, or surgical glue.

First claim

The invention claimed is:

1. Glass-based particles of a biocompatible material intermixed into a carrier for angiogenesis in wound-care management,
wherein the glass-based particles comprise from 40 to about 80 wt % borate (B 2 O 3 );
wherein the carrier is a biocompatible ointment or cream or a surgical glue for closing a wound; and
wherein the glass-based particles are angiogenic.

2. The glass-based particles intermixed into a carrier of claim 1 , wherein the glass-based particles comprise one or more alkali oxides selected from the group consisting of Li 2 O, Na 2 O, K 2 O, and Rb 2 O, and one or more alkaline earth oxides selected from the group consisting of MgO, SrO, BaO, and CaO.

3. The glass-based particles intermixed into a carrier of claim 1 , wherein the glass-based particles comprise from about 50 to about 80 wt % B 2 O 3 .

4. The glass-based particles intermixed into a carrier of claim 1 , wherein the glass-based particles comprise from about 5 to about 20 wt % of one or more alkali oxides selected from the group consisting of Li 2 O, Na 2 O, K 2 O, and Rb 2 O, and from about 5 to about 40 wt % of one or more alkaline earth oxides selected from the group consisting of MgO, SrO, BaO, and CaO.

5. The glass-based particles intermixed into a carrier of claim 1 wherein the carrier is the biocompatible ointment or cream.

6. The glass-based particles intermixed into a carrier of claim 5 wherein the glass-based particles further comprise one or more trace elements selected from the group consisting of Ag, Cu, F, Fe, Mn, Mo, Ni, Sr, and Zn in a concentration between about 0.05 and 10 wt % per trace element chemically dissolved in glass.

7. The glass-based particles intermixed into a carrier of claim 5 wherein the glass-based particles further comprise Cu in a concentration between about 0.05 and 10 wt % chemically dissolved in the glass.

8. The glass-based particles intermixed into a carrier of claim 6 wherein the one or more trace elements comprise Cu in a concentration which is between 0.1 and 2.5 wt %.

9. The glass-based particles intermixed into a carrier of claim 6 wherein the one or more trace elements comprise 0.05 to 5 wt % Zn.

10. The glass-based particles intermixed into a carrier of claim 5 wherein the glass-based particles comprise from about 50 to about 80 wt % B 2 O 3 , 1 to 25 wt % Na 2 O, 1 to 25% K 2 O, 1 to 40 wt % CaO, 1 to 25 wt % MgO, and 1 to 10 wt % P 2 O 5 .

11. The glass-based particles intermixed into a carrier of claim 6 wherein the glass-based particles comprise from about 50 to about 80 wt % B 2 O 3 , 1 to 25 wt % Li 2 O, and 1 to 40 wt % CaO.

12. The glass-based particles intermixed into a carrier of claim 6 wherein the glass-based particles comprise from about 50 to about 80 wt % B 2 O 3 , 1 to 25 wt % Na 2 O, and 1 to 40 wt % CaO.

13. The glass-based particles intermixed into a carrier of claim 6 wherein the glass-based particles comprise from about 50 to about 80 wt % B 2 O 3 , 1 to 25 wt % Na 2 O, and 1 to 40 wt % BaO.

14. The glass-based particles intermixed into a carrier of claim 6 wherein any Ca concentration in the glass-based particles is strictly controlled to less than 0.5 wt %.

15. The glass-based particles intermixed into a carrier of claim 1 wherein the glass-based particles consist essentially of the B 2 O 3 from 40 to about 80 wt %; two or more alkali oxides selected from the group consisting of Li 2 O, Na 2 O, K 2 O, and Rb 2 O; and two or more alkaline earth oxides from the group consisting of MgO, SrO, BaO, and CaO; plus Cu as the trace element in the concentration between about 0.05 and 10 wt %.

16. The glass-based particles intermixed into a carrier of claim 1 wherein the carrier is the surgical glue.

17. The glass-based particles intermixed into a carrier of claim 1 wherein the particles have a particle size between about 1 and about 300 μm.

18. The glass-based particles intermixed into a carrier of claim 1 wherein the particles comprise microspheres.

19. The glass-based particles of the biocompatible material intermixed into the carrier for angiogenesis in wound-care management of claim 1 , wherein the glass-based particles comprise no silica (SiO 2 ).

20. The glass-based particles of the biocompatible material intermixed into the carrier for angiogenesis in wound-care management of claim 1 , wherein the glass-based particles comprise less than 0.1 wt % silica (SiO 2 ).

21. The glass-based particles of the biocompatible material intermixed into the carrier for angiogenesis in wound-care management of claim 1 , wherein the glass-based particles comprise silica (SiO 2 ) in a concentration of up to 18 wt %.

22. The glass-based particles intermixed into a carrier of claim 5 wherein the carrier is the biocompatible ointment.

23. The glass-based particles intermixed into a carrier of claim 5 wherein the carrier is the biocompatible cream.

Assignees

• Univ Missouri

Inventors

• Jung Steven B
• Day Delbert E

Classifications

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61L26/0009

  containing macromolecular materials · CPC title

• A61L15/64

  specially adapted to be resorbable inside the body · CPC title

• A61L15/425

  Porous materials, e.g. foams or sponges · CPC title

• A61L15/18 Primary

  containing inorganic materials · CPC title