Controlling calcium compound formation in biocompatible materials for tissue regeneration and repair in mammals

Patent metadata

Field	Value
Publication number	US-9561303-B2
Application number	US-201213543115-A
Country	US
Kind code	B2
Filing date	Jul 6, 2012
Priority date	Jan 6, 2010
Publication date	Feb 7, 2017
Grant date	Feb 7, 2017

Abstract

A biocompatible composition for tissue repair or regeneration in mammals comprising one or more glass former compounds selected from the group consisting of B 2 O 3 , P 2 O 5 , and SiO 2 and director elements selected from the group consisting of Cu, Sr, Zn, Fe, Mn, Cr, V, Nb, Mo, W, Ba, Co, S, Al, Ti, Y, Mg, Si and/or Ni to promote in vivo calcium compound formation of calcium carbonate or other calcium compounds other than hydroxyapatite. Upon direct application of the biocompatible composition to a mammalian host, calcium carbonate or other calcium compounds other than hydroxyapatite form upon bioreaction of the composition with bodily fluids.

First claim

The invention claimed is:

1. A biocompatible composition for tissue repair or regeneration in mammals comprising:
40 to 80 wt % B 2 O 3 ;
2.5 to 50 wt % CaO;
one or more of MgO, SrO, and combinations thereof in a cumulative concentration of 5 to 40 wt %;
one or more of Li 2 O, Na 2 O, K 2 O, Rb 2 O and combinations thereof;
one or more director elements selected from the group consisting of Cu, Zn, Fe, Mn, Ba, Co, S, V, and/or Y in a cumulative concentration between 0.05 and 5 wt % to promote in vivo calcium compound formation of calcium carbonate or other calcium-containing materials other than hydroxyapatite;
wherein upon direct application of the biocompatible composition to a mammalian host, calcium carbonate or other calcium-containing materials other than hydroxyapatite form upon bioreaction of the composition with bodily fluids;
wherein the composition is in a form of one or more of fibers, hollow fibers, tubes, ribbons, solid spheres, hollow spheres, particles, bonded particles, and combinations thereof assembled in a scaffold which has a porosity of between about 15 and about 90 vol % with at least about 75 vol % of pores being interconnected and suitable for application to a mammalian host such that it is exposed to the mammalian host's bodily fluids for tissue repair or regeneration in mammals; and
wherein the composition is not water soluble.

2. The biocompatible composition of claim 1 wherein said calcium carbonate or other calcium-containing materials other than hydroxyapatite that forms upon bioreaction of the composition with bodily fluids comprises calcite; and
wherein hydroxyapatite also forms upon bioreaction of the composition with bodily fluids.

3. The biocompatible composition of claim 1 wherein hydroxyapatite does not form upon bioreaction of the composition with bodily fluids.

4. The biocompatible composition of claim 3 wherein the director element is selected from the group consisting of Cu, Zn, Fe, Mn, Ba, Co, and/or S.

5. The biocompatible composition of claim 3 wherein the director element is selected from the group consisting of Cu, Mn, Ba, Co, and/or S.

6. The biocompatible composition of claim 3 wherein the director element is Zn and/or Fe.

7. The biocompatible composition of claim 1 comprising, approximately:
40 to 80 wt % B 2 O 3
1 to 25 wt % Na 2 O
1 to 25% K 2 O
5 to 40 wt % CaO
1 to 25 wt % MgO
1 to 10 wt % P 2 O 5
said one or more director elements;
said one or more of Li 2 O, Rb 2 O, SiO 2 , Al 2 O 3 , and F.

8. The biocompatible composition of claim 1 consisting of approximately:
40 to 80 wt % B 2 O 3
1 to 25 wt % Na 2 O
1 to 25% K 2 O
5 to 40 wt % CaO
1 to 25 wt % MgO
1 to 10 wt % P 2 O 5
and said one or more director elements,
one or more of Li 2 O, Rb 2 O, SiO 2 , Al 2 O 3 , and F.

9. The biocompatible composition of claim 1 comprising, approximately:
40 to 80 wt % B 2 O 3
1 to 25 wt % Na 2 O
1 to 25% K 2 O
12 to 24 wt % CaO
1 to 25 wt % MgO
1 to 10 wt % P 2 O 5
0.1 to 2.5 wt % CuO.

10. The biocompatible composition of claim 1 comprising, approximately:
40 to 80 wt % B 2 O 3
1 to 25 wt % Na 2 O
1 to 25% K 2 O
5 to 40 wt % CaO
1 to 25 wt % MgO
1 to 10 wt % P 2 O 5
0.1 to 2.5 wt % CuO.

11. The biocompatible composition of claim 1 comprising, approximately:
40 to 80 wt % B 2 O 3
1 to 25 wt % Na 2 O
1 to 25% K 2 O
5 to 40 wt % CaO
1 to 25 wt % MgO
1 to 10 wt % P 2 O 5
0.1 to 2.5 wt % CuO
0.1 to 2.5 wt % ZnO.

12. The biocompatible composition of claim 1 comprising, approximately:
40 to 80 wt % B 2 O 3
1 to 25 wt % Na 2 O
1 to 25% K 2 O
5 to 40 wt % CaO
1 to 25 wt % MgO
1 to 10 wt % P 2 O 5
0.1 to 2.5 wt % CuO
0.1 to 2.5 wt % ZnO
0.1 to 2.5 wt % Fe 2 O 3
wherein the one or more director elements is supplied by said CuO, ZnO, and/or Fe 2 O 3 .

13. A biocompatible composition for tissue repair or regeneration in mammals comprising, approximately:
40 to 80 wt % B 2 O 3
1 to 25 wt % Na 2 O
1 to 25% K 2 O
5 to 40 wt % CaO
1 to 25 wt % MgO
1 to 10 wt % P 2 O 5
one or more director elements selected from the group consisting of Cu, Zn, Fe, Mn, Ba, Co, S, V, and/or Y in a cumulative concentration between 0.05 and 5 wt % to promote in vivo calcium compound formation of calcium carbonate or other calcium-containing materials other than hydroxyapatite;
optionally one or more of Li 2 O, Rb 2 O, SiO 2 , Al 2 O 3 , and F;
wherein the composition is in the form of a scaffold of glass fibers;
wherein the scaffold has a porosity of between about 15 and about 90 vol % with at least about 75 vol % of pores being interconnected;
wherein the glass fibers have lengths between about 2 and about 150 mm and a length:diameter aspect ratio of at least 5:1;
wherein the composition is not water soluble.

14. The biocompatible composition of claim 3 wherein the composition comprises from 10 to 90 wt % of components having one composition and from 10 to 90 wt % of components of a different composition.

15. The biocompatible composition of claim 3 wherein the composition is in the form of fibers and spheres.

16. The biocompatible composition of claim 1 wherein the one or more director elements are Zn and Fe.

17. The biocompatible composition of claim 1 wherein the one or more director elements is Zn.

18. The biocompatible composition of claim 1 wherein the one or more director elements is Fe.

19. The composition of claim 1 comprising fibers having a diameter between 20 and 5000 microns.

20. The composition of claim 1 comprising fibers having a diameter between 100 and 300 microns.

21. The composition of claim 1 comprising particles having a particle size in the range of 150 to 300 microns.

Assignees

• Jung Steven B
• Day Delbert E
• Univ Missouri

Inventors

• Jung Steven B
• Day Delbert E

Classifications

• A61L27/10 Primary

  Ceramics or glasses · CPC title

• A61L27/58

  Materials at least partially resorbable by the body · CPC title

• A61F2/0077

  Special surfaces of prostheses, e.g. for improving ingrowth (A61F2/30767 takes precedence) · CPC title