Porous material and methods related thereto

Patent metadata

Field	Value
Publication number	US-10450399-B2
Application number	US-201615096882-A
Country	US
Kind code	B2
Filing date	Apr 12, 2016
Priority date	Apr 12, 2016
Publication date	Oct 22, 2019
Grant date	Oct 22, 2019

Abstract

Disclosed herein is an aerogel made from a polyhydroxy benzene compound crosslinked with formaldehyde. The aerogel is dry and has a first volume and wherein the aerogel can be exposed to a liquid and be re-dried in a gas while retaining at least 70% of the first volume.

First claim

We claim:

1. An aerogel comprising a matrix of a polyhydroxy benzene compound crosslinked with formaldehyde, wherein aluminum acetate is dispersed within the aerogel, wherein the aerogel is dry and has a first volume, wherein the aerogel can be exposed to water and be re-dried in air while retaining at least 70% of the first volume.

2. The aerogel of claim 1 , wherein the aerogel is hydrophilic.

3. The aerogel of claim 1 , wherein the aerogel is hydrophobic.

4. The aerogel of claim 1 , wherein the polyhydroxy benzene compound is resorcinol.

5. The aerogel of claim 1 , wherein the molar ratio of the polyhydroxy benzene compound to formaldehyde in the aerogel is from about 1:1 to about 1:4.

6. The aerogel of claim 1 , wherein the aerogel can be exposed to water and be re-dried in air while retaining at least 90% of the first volume.

7. An aerogel comprising a matrix of a polyhydroxy benzene compound crosslinked with formaldehyde, wherein aluminum acetate is dispersed within the aerogel, wherein the aerogel is dry and has a first volume, wherein the aerogel can be exposed to water and be re-dried in air while retaining at least 70% of the first volume, wherein the aerogel is functionalized with a chemical linker, wherein the chemical linker comprises a reactive moiety, wherein the chemical linker comprises an amine, an amide, a silane, an azide, or a thiol.

8. The aerogel of claim 7 , wherein the functionalized aerogel further comprises a signaling moiety, wherein the chemical linker is bound to both the signaling moiety and the aerogel, wherein the signaling moiety comprises a detection portion and a target binding portion.

9. A method of making the aerogel of claim 1 comprising the steps of:
a) crosslinking a polyhydroxy benzene compound with formaldehyde in the presence of aluminum acetate, thereby forming a gel having a first volume; and
b) drying the gel in gas, thereby forming an aerogel having a second volume.

10. A method comprising
a. incubating a sample obtained from a subject with the aerogel of claim 8 ; and
b. determining the presence or absence of a biomarker for a biological condition in the sample using the signaling moiety of the aerogel,
wherein the presence of the biomarker indicates the subject has a biological condition,
wherein the absence of the biomarker indicates the subject does not have a biological condition.

11. A method of detecting comprising the steps of:
a. incubating a sample with the aerogel of claim 8 ; and
b. detecting the presence or absence of a biomarker for a biological condition in the sample using the signaling moiety of the aerogel.

12. A device comprising the aerogel of claim 1 .

13. An aerogel produced by a method comprising the steps of:
a. crosslinking a polyhydroxy benzene compound with formaldehyde in the presence of aluminum acetate, thereby forming a gel having a first volume; and
b. drying the gel in gas, thereby forming an aerogel having a second volume, wherein the aerogel is the aerogel of claim 1 .

14. An aerogel comprising a matrix of a polyhydroxy benzene compound crosslinked with formaldehyde, wherein aluminum acetate is dispersed within the aerogel, wherein the aerogel is dry and has a first volume, wherein the aerogel can be exposed to water and be re-dried in air while retaining at least 70% of the first volume, wherein the aerogel is a functionalized with an alkyl group, an alkenyl group, or an alkynyl group.

Assignees

• Southern Res Inst

Inventors

• CAIN Andrew Wayne
• Parks William Madison
• Boohaker Rebecca J
• Pathak Ashish
• Chakraborty Saibal

Classifications

• B01J13/0091

  Preparation of aerogels, e.g. xerogels · CPC title

• C08G8/22 Primary

  Resorcinol · CPC title

• C12Q1/6816

  characterised by the detection means (C12Q1/6804 takes precedence) · CPC title