Use of an organic citrus extract with high antimicrobial capacity and xylitol as a preservative system in liquids, emulsions, suspensions, creams and antacids

Patent metadata

Field	Value
Publication number	US-10342841-B2
Application number	US-201615165275-A
Country	US
Kind code	B2
Filing date	May 26, 2016
Priority date	May 29, 2015
Publication date	Jul 9, 2019
Grant date	Jul 9, 2019

Abstract

Liquid antacid compositions containing citrus extract are disclosed. The liquid antacid compositions possess superior resistance to microbial attack.

First claim

The invention claimed is:

1. A liquid antacid composition comprising:
a) an antacid, wherein said antacid is selected from the group consisting of aluminum hydroxide; calcium hydroxide; magnesium hydroxide, sodium bicarbonate, and magnesium oxide;
b) about 0.025 mg/ml to about 1.9 mg/ml of a citrus extract, wherein the citrus extract comprises citrus aurantium amara (CAS 72968-50-4), citrus reticulata (CAS 84929-38-4), and citrus sinesis (CAS 8028-48-6);
c) xylitol; and
d) optionally, one or more other pharmaceutically acceptable excipients;
wherein said liquid antacid composition meets the requirements of USP NF 37—category 4-antacids: no increase from the initial calculated count at 14 and 28 days for bacteria, yeast and molds;
wherein the pH of the composition is about 7 to about 9.

2. The liquid antacid composition of claim 1 , wherein the antacid is magnesium hydroxide.

3. The liquid antacid composition of claim 1 , wherein the antacid is aluminum hydroxide.

4. A method for neutralizing excess stomach acid in a human or lower animal, comprising orally administering to said human or lower animal an effective amount of the liquid antacid composition of claim 1 .

5. A method for the treatment of a gastrointestinal disorder in a human or lower animal, comprising administering to said human or lower animal an effective amount of the liquid antacid composition of claim 1 .

6. The method of claim 5 wherein the gastrointestinal disorder is selected from the group consisting of acid indigestion, heartburn, dyspepsia, sour stomach, reflux esophagitis, hiatal hernia and flatulence symptoms.

7. The liquid antacid composition of claim 1 , further comprising a preservative selected from the group consisting of butylparaben, methylparaben and propylparaben.

8. The liquid antacid composition of claim 1 , further comprising a pharmaceutically effective amount of a histamine H2 receptor antagonist.

9. The liquid antacid composition of claim 8 , wherein the histamine H2 receptor antagonist is selected from the group consisting of cimetidine, ranitidine, nizatidine and famotidine.

10. The liquid antacid composition of claim 1 , further comprising sorbitol.

11. The liquid antacid composition of claim 1 , further comprising simethicone.

Assignees

• Johnson & Johnson Consumer Inc

Inventors

• Barraza Javier
• Muniz Renata

Classifications

• A61P1/14

  Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents · CPC title

• A61K9/00

  Medicinal preparations characterised by special physical form {(nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations A61K49/18; preparations containing radioactive substances A61K51/12)} · CPC title

• A61K33/06

  Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay} · CPC title

• A61K31/045

  Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates · CPC title

• A61P1/00

  Drugs for disorders of the alimentary tract or the digestive system · CPC title