Effervescent dosage form

Patent metadata

Field	Value
Publication number	US-10322144-B2
Application number	US-201816015224-A
Country	US
Kind code	B2
Filing date	Jun 22, 2018
Priority date	Jun 12, 2012
Publication date	Jun 18, 2019
Grant date	Jun 18, 2019

Abstract

An effervescent chewable dosage form that comprises a pH neutralization agent, an acid, and an effervescent agent. The chewable dosage form can also further comprise simethicone, a sweetener, and a lubricant. The pH neutralization agent can be calcium carbonate, the acid can be citric acid and the effervescent agent can be sodium bicarbonate.

First claim

What is claimed is:

1. A method of providing heartburn relief comprising administering an effervescent chewable dosage form to a subject in need thereof, wherein the effervescent chewable dosage form comprises:
a. from about 28% to about 34% of a pH neutralization agent; wherein the pH neutralization agent is calcium carbonate;
b. from about 4% to about 6% of citric acid;
c. from about 5% to about 7% of an effervescent agent; wherein the effervescent agent is sodium bicarbonate;
d. from about 2% to about 9% of a gas reducer; wherein the gas reducer is simethicone; and
e. from about 35% to about 50% of a nutritive sweetener;
wherein the effervescent chewable dosage form is a tablet.

2. The method of providing heartburn relief of claim 1 wherein the effervescent chewable dosage form further comprises from about 0.05% to about 5% of a synthetic sweetener.

3. The method of providing heartburn relief of claim 1 wherein the effervescent chewable dosage form has a gas evolution of from about 24 mL to 32 mL.

4. The method of providing heartburn relief of claim 1 wherein the effervescent chewable dosage form further comprises starch.

5. The method of providing heartburn relief of claim 1 wherein the effervescent chewable dosage form has a tablet breaking force of about 3 kp to about 12 kp.

6. The method of providing heartburn relief of claim 1 wherein the effervescent chewable dosage form has a tablet breaking force of about 4 kp to about 8.5 kp.

7. The method of providing heartburn relief of claim 1 wherein the effervescent chewable dosage form has a molar ratio of effervescent agent to acid of from about 0.5:1 to about 6:1.

Assignees

• Procter & Gamble

Inventors

• Stella Mark Edward
• Entwisle John Richard
• Newlon Jason William
• Naykki Christine Louis

Classifications

• A61K31/695

  Silicon compounds · CPC title

• A61K9/2036

  Silicones; Polysiloxanes · CPC title

• A61K9/2013

  Organic compounds, e.g. phospholipids, fats · CPC title

• A61K9/2059

  Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin · CPC title

• A61K9/2018

  Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates · CPC title