Fluid infection using acoustic waves

Patent metadata

Field	Value
Publication number	US-10258987-B2
Application number	US-201515320408-A
Country	US
Kind code	B2
Filing date	Jun 25, 2015
Priority date	Jun 26, 2014
Publication date	Apr 16, 2019
Grant date	Apr 16, 2019

Abstract

The present invention generally relates to the manipulation of fluids using acoustic waves such as surface acoustic waves. In some aspects, one fluid may be introduced into another fluid via application of suitable acoustic waves. For example, a fluid may be added or injected into another fluid by applying acoustic waves where, in the absence of the acoustic waves, the fluid cannot be added or injected, e.g., due to the interface or surface tension between the fluids. Thus, for example, a fluid may be injected into a droplet of another fluid. Other embodiments of the invention are generally directed to systems and methods for making or using such systems, kits involving such systems, or the like.

First claim

What is claimed is:

1. A method, comprising:
providing a microfluidic system comprising a first microfluidic channel and a second microfluidic channel contacting the first microfluidic channel at a junction;
providing a droplet of the first fluid contained by a carrying fluid in the first microfluidic channel, and a second fluid in the second microfluidic channel, wherein the first fluid and the second fluid contact each other at least partially within the junction to define a fluidic interface; and
applying acoustic waves to the interface to urge the second fluid to flow into the droplet wherein, in the absence of the acoustic waves, the second fluid is not urged to enter the droplet.

2. The method of claim 1 , wherein the acoustic waves are applied to at least a portion of the junction.

3. The method of claim 1 , wherein the acoustic waves are applied to the first fluid in a direction of flow of the first fluid.

4. The method of claim 1 , wherein the acoustic waves are applied to the first fluid opposite a direction of flow of the first fluid.

5. The method of claim 1 , wherein the acoustic waves are applied to the second fluid in a direction of flow of the second fluid.

6. The method of claim 1 , wherein the acoustic waves are applied to the second fluid opposite a direction of flow of the second fluid.

7. The method of claim 1 , wherein the acoustic waves have a power of at least about 3 dBm.

8. The method of claim 1 , wherein the acoustic waves have an average frequency of between about 430 MHz and about 160 MHz.

9. The method of claim 1 , wherein the acoustic waves have an average frequency of between about 140 MHz and about 150 MHz.

10. The method of claim 1 , further comprising applying pressure to the second fluid contained within the second microfluidic channel sufficient to cause at least a portion of the second fluid to enter the droplet of the first fluid.

11. The method of claim 1 , wherein the first microfluidic channel and the second microfluidic channel from a T junction.

12. The method of claim 1 , wherein the acoustic waves are generated by an acoustic wave generator.

13. The method of claim 12 , wherein the acoustic wave generator comprises one or more interdigited transducers.

14. The method of claim 1 , further comprising a second acoustic wave generator positioned to alter flow of fluid entering or leaving the junction.

15. The method of claim 1 , wherein the microfluidic system comprises a piezoelectric substrate.

16. A method, comprising:
providing a microfluidic system comprising a first fluid contacting a second fluid at an interface separating the first fluid and the second fluid; and
applying acoustic waves to the interface, wherein the acoustic waves disrupt the interface to cause at least some mixing of the first fluid and the second fluid.

17. The method of claim 16 , wherein the acoustic waves are applied to the first fluid in a direction of flow of the first fluid.

18. The method of claim 16 , wherein the acoustic waves are applied to the second fluid in a direction of flow of the second fluid.

19. The method of claim 16 , wherein the acoustic waves have a power of at least about 3 dBm.

20. The method of claim 16 , wherein the acoustic waves are generated by an acoustic wave generator comprising one or more interdigited transducers.

Assignees

• Harvard College
• Univ Glasgow Court

Inventors

• Weitz David A
• Franke Thomas

Classifications

• B01J2219/00833

  Plastic · CPC title

• B01J2219/00932

  Sonic or ultrasonic vibrations · CPC title

• C07K14/415

  from plants · CPC title

• C12N15/8243

  involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine · CPC title

• B01L2400/0487

  fluid pressure, pneumatics · CPC title