Anti-virulence compositions and methods

Patent metadata

Field	Value
Publication number	US-10227282-B2
Application number	US-201414445713-A
Country	US
Kind code	B2
Filing date	Jul 29, 2014
Priority date	Mar 8, 2010
Publication date	Mar 12, 2019
Grant date	Mar 12, 2019

Abstract

A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.

First claim

Having described the invention, the following is claimed:

1. A pharmaceutical composition comprising an accessory gene regulator A (AgrA) antagonist having the formula:

and pharmaceutically acceptable salts thereof, and an antibiotic.

2. A pharmaceutical composition comprising an accessory gene regulator A (AgrA) antagonist having the formula:

wherein R 1 and R 2 are each independently selected from the group consisting of H, hydroxy, carboxy, lower alkoxy, lower alkoxyhydroxy, lower alkyl, alkenyl, sulfonic, and halo; R 3 is a C2-C6 lower alkyl;
and pharmaceutically acceptable salts thereof, and an antibiotic.

Assignees

• Univ Case Western Reserve

Inventors

• Shoham Menachem

Classifications

• A61P31/04

  Antibacterial agents · CPC title

• C12N1/36

  Adaptation or attenuation of cells · CPC title

• A61P19/02

  for joint disorders, e.g. arthritis, arthrosis · CPC title

• C07C49/83 Primary

  polycyclic · CPC title

• A61K31/12 Primary

  Ketones · CPC title