Solution solubilization composition of insoluble material and method for solubilizing insoluble material using same

Patent metadata

Field	Value
Publication number	US-10226413-B2
Application number	US-201315033021-A
Country	US
Kind code	B2
Filing date	Nov 15, 2013
Priority date	Nov 15, 2013
Publication date	Mar 12, 2019
Grant date	Mar 12, 2019

Abstract

The present invention relates to a solution solubilization composition of an insoluble material and a method for solubilizing an insoluble material using the same, on the basis of the mechanism that a solution solubilization composition of an insoluble material comprising mannosylerythritol lipid, an insoluble material, a heteropolysaccharide, a surfactant and a polyol offsets the intermolecular interaction of a hydrophobic material without physical requirements.

First claim

What is claimed is:

1. A composition for solubilizing a substance in water, comprising a combination of:
(a) a mannosylerythritol lipid;
(b) a heteropolysaccharide;
(c) a surfactant; and
(d) a polyol,

wherein the combination forms an organic solution and wherein the composition comprises 100 parts by weight of the mannosylerythritol lipid, 0.1 to 100 parts by weight of the heteropolysaccharide containing galactose, glucose, and mannose units, 10 to 4500 parts by weight of the surfactant, and 10 to 3000 parts by weight of the polyol.

2. The composition according to claim 1 , wherein the mannosylerythritol lipid is represented by Formula 1:

wherein R 1 and R 2 are identical to or different from each other and are each independently a C 6- , C 12 - or C 14 -chain saturated or unsaturated fatty acid and R 3 is an acetyl group.

3. The composition according to claim 1 , wherein the heteropolysaccharide contains galactose, glucose, and mannose units in a molar ratio of 1-3:3-6:1-3.

4. The composition according to claim 1 , wherein the heteropolysaccharide is produced from Candida sp.

5. The composition according to claim 1 comprising a first heteropolysaccharide having a molecular weight of 50000 to 80000 daltons, a second heteropolysaccharide having a molecular weight of 20000 to 50000 daltons, a third heteropolysaccharide having a molecular weight of 5000 to 20000 daltons, a fourth polysaccharide having a molecular weight of 140000 to 160000 daltons, and a fifth polysaccharide having a molecular weight of 160000 to 180000 daltons.

6. The composition according to claim 1 , wherein the surfactant is selected from polyoxyethylene hydrogenated castor oil, Ceteareth, Ceteth, Glycereth, Laureth, Oleth, Polysorbates, Steareth, amino acid-fatty acid esters, polyoxyethylene stearate, and mixtures thereof.

7. The composition according to claim 1 , wherein the polyol is selected from butylene glycol, dipropylene glycol, propylene glycol, caprylyl glycol, decylene glycol, ethylene glycol, hexylene glycol, polyethylene glycol, glycerin, diglycerin, ethylhexylglycerin, polyglycerin, 1,6-hexanediol, 1,2-hexanediol, 1,2-octanediol, and mixtures thereof.

8. The composition according to claim 1 , further comprising a substance selected from ceramide, rutein, resveratrol, phylloquinone, ubiquinone, oleanolic acid, bis-ethylhexyloxyphenol methoxyphenyl triazine, astaxanthin, rutin, hesperidin, chloramphenicol, and mixtures thereof that are used in a cosmetic or pharmaceutical composition.

9. A method for solubilizing a substance in water, comprising:
(i) sequentially mixing a mannosylerythritol lipid, a selected substance for delivery, a heteropolysaccharide, a surfactant, and a polyol, wherein the composition comprises 100 parts by weight of the mannosylerythritol lipid, 0.1 to 100 parts by weight of the heteropolysaccharide containing galactose, glucose, and mannose units, 10 to 4500 parts by weight of the surfactant, and 10 to 3000 parts by weight of the polyol; and
(ii) heating and stirring the mixture to form an organic solution.

10. The method according to claim 9 , wherein the mixture comprises 100 parts by weight of the mannosylerythritol lipid, 2 to 4000 parts by weight of the selected substance, 0.1 to 100 parts by weight of the heteropolysaccharide containing galactose, glucose, and mannose units, 10 to 4500 parts by weight of the surfactant, and 10 to 3000 parts by weight of the polyol.

11. The method according to claim 9 , wherein the mannosylerythritol lipid is represented by Formula 1:

wherein R 1 and R 2 are identical to or different from each other and are each independently a C 6 -, C 12 - or C 14 -chain saturated or unsaturated fatty acid and R 3 is an acetyl group.

12. The method according to claim 9 , wherein the heteropolysaccharide contains galactose, glucose, and mannose units in a molar ratio of 1-3:3-6:1-3.

13. The method according to claim 9 , wherein the heteropolysaccharide is produced from Candida sp.

14. The method according to claim 9 , wherein the composition comprises a first heteropolysaccharide having a molecular weight of 50000 to 80000 daltons, a second heteropolysaccharide having a molecular weight of 20000 to 50000 daltons, a third heteropolysaccharide having a molecular weight of 5000 to 20000 daltons, a fourth polysaccharide having a molecular weight of 140000 to 160000 daltons, and a fifth polysaccharide having a molecular weight of 160000 to 180000 daltons.

15. The method according to claim 9 , wherein the composition comprises polyoxyethylene hydrogenated castor oil, Ceteareth, Ceteth, Glycereth, Laureth, Oleth, Polysorbates, Steareth, amino acid-fatty acid esters, polyoxyethylene stearate, or mixtures thereof.

16. The method according to claim 9 , wherein the polyol is selected from butylene glycol, dipropylene glycol, propylene glycol, caprylyl glycol, decylene glycol, ethylene glycol, hexylene glycol, polyethylene glycol, glycerin, diglycerin, ethylhexylglycerin, polyglycerin, 1,6-hexanediol, 1,2-hexanediol, 1,2-octanediol, and mixtures thereof.

17. The method according to claim 9 , wherein the selected substance is selected from ceramide, rutein, resveratrol, phylloquinone, ubiquinone, oleanolic acid, bis-ethylhexyloxyphenol methoxyphenyl triazine, astaxanthin, rutin, hesperidin, chloramphenicol, and mixtures thereof that are used in a cosmetic or pharmaceutical composition.

18. The method according to claim 9 , wherein the heating temperature is from 40 to 80° C.

Assignees

• Damy Chemical Co Ltd
• Korea Res Inst Bioscience & Biotechnology
• Korea Res Institute Of Bioscience And Biotech

Inventors

• Kim Kwang-Nyeon
• Son Ju-Hyun
• Kim Hee-Sik

Classifications

• A61K31/122

  having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin · CPC title

• A61K31/19

  Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60) · CPC title

• A61K31/164

  of a carboxylic acid with an aminoalcohol, e.g. ceramides · CPC title

• A61K8/68 Primary

  Sphingolipids, e.g. ceramides, cerebrosides, gangliosides · CPC title

• A61K9/1075

  Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers (A61K9/0026 takes precedence) · CPC title