Composition for skin improvement comprising hexamidines and retinoids

Patent metadata

Field	Value
Publication number	US-9504662-B2
Application number	US-39047610-A
Country	US
Kind code	B2
Filing date	Aug 20, 2010
Priority date	Aug 20, 2009
Publication date	Nov 29, 2016
Grant date	Nov 29, 2016

Abstract

Disclosed is herein a composition comprising hexamidines, derivatives thereof, or pharmaceutically acceptable salts thereof; and retinoids, derivatives thereof, or pharmaceutically acceptable salts thereof, as an active ingredient. The composition of the present invention has effects for preventing, improving or treating acne; controlling sebum; pore-controlling; and preventing, improving or treating skin pigmentation. Also, the composition of the present invention could alleviate skin-irritations caused with retinoids by including ceramides.

First claim

We claim:

1. A method for improving skin condition of a subject, comprising:
administering to the subject a composition comprising an effective amount of hexamidine, retinol, and ceramide that improve skin condition in the subject;
wherein the ceramide is in an amount of 0.2 wt % to 5.0 wt % based on a total weight of the composition;
wherein the hexamidine is in an amount of 0.1 wt % based on the total weight of the composition,
wherein the retinol is in an amount of 0.05 wt % to 0.3 wt % based on the total weight of the composition,
wherein the improving skin condition of the subject is selected from the group consisting of improving or treating acne of the subject, controlling sebum of the subject, controlling pores of the subject, and improving or treating skin pigmentation of the subject,
wherein the ceramide alleviates skin irritation caused by the retinol, and
wherein the ceramide is represented by Chemical Formula 2:

wherein n is 1 or 2; and each of R and R′ represents a C 9 -C 21 saturated or unsaturated aliphatic chain.

2. The method according to claim 1 , wherein the improving skin condition of the subject comprises improving or treating acne of the subject.

3. The method according to claim 1 , wherein the improving skin condition of the subject comprises controlling sebum of the subject.

4. The method according to claim 1 , wherein the improving skin condition of the subject comprises controlling pores of the subject.

5. The method according to claim 1 , wherein the improving skin condition of the subject comprises improving or treating skin pigmentation of the subject.

Assignees

• Park Jong Hee
• Park Shin Young
• Shin Hong-Ju
• Kim Do-Hoon
• Yi Chang-Geun
• Park Won Seok
• Koh Hyun Ju
• Kim Jeong-Hwan
• Kim Hyoung Jun
• Amorepacific Corp

Inventors

• Park Jong Hee
• Park Shin Young
• Shin Hong-Ju
• Kim Do-Hoon
• Yi Chang-Geun
• Park Won Seok
• Koh Hyun Ju
• Kim Jeong-Hwan
• Kim Hyoung Jun

Classifications

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P17/10

  Anti-acne agents · CPC title

• A61K31/155 Primary

  Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2) · CPC title

• A61K8/671

  Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal · CPC title

• A61K31/07

  Retinol compounds, e.g. vitamin A (retinoic acids A61K31/203) · CPC title