Solution solubilization composition of insoluble material and method for solubilizing insoluble material using same

Patent metadata

Field	Value
Publication number	US-2016250129-A1
Application number	US-201315033021-A
Country	US
Kind code	A1
Filing date	Nov 15, 2013
Priority date	Nov 15, 2013
Publication date	Sep 1, 2016
Grant date	—

Abstract

The present invention relates to a solution solubilization composition of an insoluble material and a method for solubilizing an insoluble material using the same, on the basis of the mechanism that a solution solubilization composition of an insoluble material comprising mannosylerythritol lipid, an insoluble material, a heteropolysaccharide, a surfactant and a polyol offsets the intermolecular interaction of a hydrophobic material without physical requirements.

First claim

What is claimed is:

1 . A composition for solubilizing a poorly soluble substance in water, comprising:
(a) a mannosylerythritol lipid; (b) a heteropolysaccharide; (c) a surfactant; and (d) a polyol.

2 . The composition according to claim 1 , wherein the composition comprises 100 parts by weight of the mannosylerythritol lipid (a), 0.1 to 100 parts by weight of the heteropolysaccharide containing galactose, glucose, and mannose units (b), 10 to 4500 parts by weight of the surfactant (c), and 10 to 3000 parts by weight of the polyol (d).

3 . The composition according to claim 1 , wherein the mannosylerythritol lipid (a) is represented by Formula 1:

wherein R 1 and R 2 are identical to or different from each other and are each independently a C 6 -, C 12 - or C 14 -chain saturated or unsaturated fatty acid and R 3 is an acetyl group.

4 . The composition according to claim 1 , wherein the heteropolysaccharide (b) contains galactose, glucose, and mannose units in a molar ratio of 1-3:3-6:1-3.

5 . The composition according to claim 1 , wherein the heteropolysaccharide (b) is produced from Candida sp.

6 . The composition according to claim 1 , wherein the heteropolysaccharide (b) consists of a first polysaccharide having a molecular weight of 50000 to 80000 daltons, a second polysaccharide having a molecular weight of 20000 to 50000 daltons, a third polysaccharide having a molecular weight of 5000 to 20000 daltons, a fourth polysaccharide having a molecular weight of 140000 to 160000 daltons, and a fifth polysaccharide having a molecular weight of 160000 to 180000 daltons.

7 . The composition according to claim 1 , wherein the surfactant (c) is selected from polyoxyethylene hydrogenated castor oil, Ceteareth, Ceteth, Glycereth, Laureth, Oleth, Polysorbates, Steareth, amino acid-fatty acid esters, polyoxyethylene stearate, and mixtures thereof.

8 . The composition according to claim 1 , wherein the polyol (d) is selected from butylene glycol, dipropylene glycol, propylene glycol, caprylyl glycol, decylene glycol, ethylene glycol, hexylene glycol, polyethylene glycol, glycerin, diglycerin, ethylhexylglycerin, polyglycerin, 1,6-hexanediol, 1,2-hexanediol, 1,2-octanediol, and mixtures thereof.

9 . The composition according to claim 1 , wherein the poorly soluble substance is selected from ceramide, rutein, resveratrol, phylloquinone, ubiquinone, oleanolic acid, bis-ethylhexyloxyphenol methoxyphenyl triazine, astaxanthin, rutin, hesperidin, chloramphenicol, and mixtures thereof that are used in a cosmetic or pharmaceutical composition.

10 . A method for solubilizing a poorly soluble substance in water, comprising:
(i) sequentially mixing a mannosylerythritol lipid, a poorly soluble substance, a heteropolysaccharide, a surfactant, and a polyol; and (ii) heating and stirring the mixture.

11 . The method according to claim 10 , wherein the mixture comprises 100 parts by weight of the mannosylerythritol lipid, 2 to 4000 parts by weight of the poorly soluble substance, 0.1 to 100 parts by weight of the heteropolysaccharide containing galactose, glucose, and mannose units, 10 to 4500 parts by weight of the surfactant, and 10 to 3000 parts by weight of the polyol.

12 . The method according to claim 10 , wherein the mannosylerythritol lipid is represented by Formula 1:

wherein R 1 and R 2 are identical to or different from each other and are each independently a C 6 -, C 12 - or C 14 -chain saturated or unsaturated fatty acid and R 3 is an acetyl group.

13 . The method according to claim 10 , wherein the heteropolysaccharide contains galactose, glucose, and mannose units in a molar ratio of 1-3:3-6:1-3.

14 . The method according to claim 10 , wherein the heteropolysaccharide is produced from Candida sp.

15 . The method according to claim 10 , wherein the heteropolysaccharide consists of a first polysaccharide having a molecular weight of 50000 to 80000 daltons, a second polysaccharide having a molecular weight of 20000 to 50000 daltons, a third polysaccharide having a molecular weight of 5000 to 20000 daltons, a fourth polysaccharide having a molecular weight of 140000 to 160000 daltons, and a fifth polysaccharide having a molecular weight of 160000 to 180000 daltons.

16 . The method according to claim 10 , wherein the surfactant is selected from polyoxyethylene hydrogenated castor oil, Ceteareth, Ceteth, Glycereth, Laureth, Oleth, Polysorbates, Steareth, amino acid-fatty acid esters, polyoxyethylene stearate, and mixtures thereof.

17 . The method according to claim 10 , wherein the polyol is selected from butylene glycol, dipropylene glycol, propylene glycol, caprylyl glycol, decylene glycol, ethylene glycol, hexylene glycol, polyethylene glycol, glycerin, diglycerin, ethylhexylglycerin, polyglycerin, 1,6-hexanediol, 1,2-hexanediol, 1,2-octanediol, and mixtures thereof.

18 . The method according to claim 10 , wherein the poorly soluble substance is selected from ceramide, rutein, resveratrol, phylloquinone, ubiquinone, oleanolic acid, bis-ethylhexyloxyphenol methoxyphenyl triazine, astaxanthin, rutin, hesperidin, chloramphenicol, and mixtures thereof that are used in a cosmetic or pharmaceutical composition.

19 . The method according to claim 10 , wherein the heating temperature is from 40 to 80° C.

Assignees

• Damy Chemical Co Ltd
• Korea Res Inst Bioscience & Biotechnology

Inventors

• Kim Kwang-Nyeon
• Son Ju-Hyun
• Kim Hee-Sik

Classifications

• A61K8/73

  Polysaccharides · CPC title

• A61K8/68 Primary

  Sphingolipids, e.g. ceramides, cerebrosides, gangliosides · CPC title

• A61K31/164

  of a carboxylic acid with an aminoalcohol, e.g. ceramides · CPC title

• A61K8/9728

  Fungi, e.g. yeasts · CPC title

• A61K8/345

  containing more than one hydroxy group · CPC title