Immunogenic composition
US-11241495-B2 · Feb 8, 2022 · US
US10166287B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10166287-B2 |
| Application number | US-201715691440-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 30, 2017 |
| Priority date | Jun 27, 2005 |
| Publication date | Jan 1, 2019 |
| Grant date | Jan 1, 2019 |
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present application discloses an immunogenic composition comprising N. meningitidis capsular polysaccharides from at least one of serogroups A, C, W135 and Y conjugated to a carrier protein to produce a N. meningitidis capsular polysaccharide conjugate, wherein the average size of each N. meningitidis polysaccharide is above 50 kDa.
Opening claim text (preview).
The invention claimed is: 1. An immunogenic composition, comprising N. meningitidis capsular polysaccharides from serogroups A, C, W, and Y, wherein: the serogroup A capsular polysaccharide has an average size of 300 kDa; the serogroup C capsular polysaccharide has an average size of 200 kDa; the serogroup Y capsular polysaccharide has an average size of 101-300 kDa; the serogroup W capsular polysaccharide has an average size of 101-300 kDa; and wherein each N. meningitidis capsular polysaccharide is a N. meningitidis capsular polysaccharide conjugate comprising a N. meningitidis capsular polysaccharide conjugated to a tetanus toxoid carrier protein. 2. The immunogenic composition of claim 1 , wherein the serogroup Y capsular polysaccharide has an average size of 190-300 kDa; and the serogroup W capsular polysaccharide has an average size of 190-300 kDa. 3. An immunogenic composition, comprising N. meningitidis capsular polysaccharides from serogroups A, C, W, and Y, wherein: each of serogroups A, W, and Y capsular polysaccharide has an average size of 101-300 kDa, the serogroup C capsular polysaccharide has an average size of 200 kDa, and wherein each N. meningitidis capsular polysaccharide is a N. meningitidis capsular polysaccharide conjugate comprising a N. meningitidis capsular polysaccharide conjugated to a tetanus toxoid carrier protein. 4. The immunogenic composition of claim 3 , wherein the serogroup Y capsular polysaccharide has an average size of 190-300 kDa; and the serogroup W capsular polysaccharide has an average size of 190-300 kDa.
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