Mixed allergen compositions and methods for using the same

Patent metadata

Field	Value
Publication number	US-10149904-B2
Application number	US-201615223828-A
Country	US
Kind code	B2
Filing date	Jul 29, 2016
Priority date	Feb 20, 2015
Publication date	Dec 11, 2018
Grant date	Dec 11, 2018

Abstract

Mixed allergen compositions of one, two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin. Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.

First claim

What is claimed is:

1. A method for treating one or more food allergies in a human subject with an existing food allergy to one or more foods, the method comprising administering to the subject a mixed allergen composition comprising 2 to 20 different flours or powders, wherein at least one flour or powder is a nut flour selected from the group consisting of peanut, almond, walnut, cashew, hazelnut, pecan, and pistachio, at least one flour or powder is an animal powder selected from the group consisting of shrimp, cod, and salmon, and the mixed allergen composition comprises equal parts by protein weight of each flour or powder, and wherein the composition is administered to the subject at least weekly or at least every other week.

2. The method of claim 1 , further comprising allowing sufficient time for the administration of the composition to inhibit symptoms of food allergy in the human subject.

3. The method claim 1 , wherein the one or more food allergies is a single food allergy.

4. The method of claim 1 , wherein the one or more food allergies is a multiple food allergy.

5. The method of claim 1 , wherein the 2 to 20 different flours or powders are each selected from the group consisting of shellfish, peanut, tree nut, fish, milk, egg, legume, grain, sesame, and fruit.

6. The method of claim 5 , wherein the 2 to 20 different flours or powders are each selected from the group consisting of cashew, pistachio, walnut, almond, pecan, chicken egg, cow milk, peanut, shrimp, salmon, wheat, cod, crab, legume, and seed.

7. The method of claim 1 , wherein the administration of the composition significantly inhibits the symptoms of a food allergy in the subject as compared to administering to the subject a composition that includes only one flour or powder.

8. The method of claim 1 , wherein the human subject is a pediatric subject.

9. The method of claim 1 , wherein the human subject is an adult.

10. The method of claim 1 , wherein the composition is administered orally, nasally, topically or subcutaneously.

11. The method of claim 1 , wherein the composition is a food product.

12. The method of claim 11 , wherein the food product is a baked food product.

13. The method of claim 1 , wherein at least one flour or powder is a non-nut plant flour selected from the group consisting of wheat, sesame, and oat.

14. The method of claim 1 , wherein at least one flour or powder is powdered hen's egg.

15. The method of claim 1 , wherein at least one flour or powder is soy.

16. The method of claim 1 , wherein the mixed allergen composition comprises vitamin D.

17. The method of claim 10 , wherein the composition is administered orally.

18. A method for treating one or more food allergies in a human subject with an existing food allergy to one or more foods, the method comprising orally administering to the subject a mixed allergen unit composition comprising:
6 to 20 different flours or powders,
wherein at least one flour or powder is a nut flour selected from the group consisting of peanut, almond, walnut, cashew, hazelnut, pecan, and pistachio,
at least one flour or powder is an animal powder selected from the group consisting of shrimp, cod, salmon, milk, and egg,
at least one flour or powder is a non-nut plant flour selected from the group consisting of wheat, sesame, and oat, and
the unit composition comprises equal parts by protein weight of each flour or powder.

Assignees

• Univ Leland Stanford Junior
• The Board Of Trusteees Of The Leland Stanford Junior Univ

Inventors

• Nadeau Kari C

Classifications

• A61K2039/542

  oral/gastrointestinal · CPC title

• A61K2039/55

  characterised by the host/recipient, e.g. newborn with maternal antibodies · CPC title

• A61K47/46

  Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts · CPC title

• A61K2039/575

  humoral response · CPC title

• A61K2039/70

  Multivalent vaccine · CPC title