Method of making multi-electrode molecular sensing devices

Patent metadata

Field	Value
Publication number	US-10125420-B2
Application number	US-201715728412-A
Country	US
Kind code	B2
Filing date	Oct 9, 2017
Priority date	Jul 26, 2016
Publication date	Nov 13, 2018
Grant date	Nov 13, 2018

Abstract

A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.

First claim

What is claimed is:

1. A method of manufacturing a structure usable in a molecular sensor device, the method comprising:
forming a stack comprising:
providing a first outer dielectric layer;
depositing a first electrode layer on the first outer dielectric layer;
depositing an inner dielectric layer having a first thickness on the first electrode layer;
depositing a second electrode layer on the inner dielectric layer; and
depositing a second outer dielectric layer having a second thickness on the second electrode layer, wherein the second thickness of the second outer dielectric layer is at least one order of magnitude greater than the first thickness of the inner dielectric layer;

slicing through the stack at least once at an angle to the layers in the stack to form a plurality of chips from the sliced portions of the stack;
attaching the plurality of chips to a substrate so that the sliced portions of the first electrode layer and the second electrode layer form a plurality of pairs of electrode sheets at an angle to a substrate plane defined by the substrate, and so that the sliced portions of the inner dielectric layer forms a plurality of inner dielectric sheets with each inner dielectric sheet between each electrode sheet in each pair of electrode sheets; and
forming a groove located on an exposed end portion of each inner dielectric sheet.

2. The method of claim 1 , wherein forming the stack further includes repeating the deposition of the first electrode layer, the inner dielectric layer, the second electrode layer, and the second outer dielectric layer at least once so that each chip of the plurality of chips includes multiple pairs of electrode sheets.

3. The method of claim 1 , further comprising depositing a dielectric cover layer at an angle or perpendicular to the plurality of pairs of electrode sheets opposite the substrate to define a gap exposing a portion of the plurality of pairs of electrode sheets.

4. The method of claim 1 , further comprising roughening an exposed edge of each electrode sheet.

5. The method of claim 1 , further comprising depositing a gate electrode parallel to the substrate plane and perpendicular to an electrode plane defined by an electrode sheet in the plurality of pairs of electrode sheets.

6. The method of claim 1 , further comprising forming a plurality of channels, each channel arranged to introduce a fluid to exposed portions of at least two pairs of electrode sheets of the plurality of pairs of electrode sheets.

7. The method of claim 1 , wherein the groove is formed by etching the inner dielectric sheet using an etching process selecting from the group consisting of RIE, sputter etch, and a chemical etch.

8. The method of claim 1 , wherein each of the inner dielectric sheets is no more than 50 nm thick.

9. The method of claim 1 , further comprising connecting a plurality of lead conductors to the plurality of pairs of electrode sheets with each lead conductor connected to a respective electrode sheet.

Assignees

• Roswell Biotechnologies Inc

Inventors

• Jin Sungho
• Merriman Barry L
• Geiser Tim
• Choi Chulmin
• Mola Paul

Classifications

• C12Q1/6869

  Methods for sequencing · CPC title

• G01N27/3278

  involving nanosized elements, e.g. nanogaps or nanoparticles (nanopores G01N33/48721; magnetic beads G01N27/745) · CPC title

• B81B2201/0214

  Biosensors; Chemical sensors · CPC title

• B81B2203/04

  Electrodes · CPC title

• B81C1/00126

  Static structures not provided for in groups B81C1/00031 - B81C1/00119 · CPC title