Filtration cassette and a stack of filtration cassettes

Patent metadata

Field	Value
Publication number	US-10105622-B2
Application number	US-201314403673-A
Country	US
Kind code	B2
Filing date	May 29, 2013
Priority date	May 30, 2012
Publication date	Oct 23, 2018
Grant date	Oct 23, 2018

Abstract

The invention discloses a normal flow filtration cassette ( 1 ) stackable with like cassettes, said cassette comprising: at least three port conduits ( 2,3,4 ); an inlet chamber ( 5 ) in fluid communication at least with a first of said port conduits ( 2 ); an outlet chamber ( 6 ) in fluid communication at least with a second of the port conduits ( 3 ); and a filter medium ( 7 ) between said inlet chamber and said outlet chamber, wherein said at least three port conduits ( 2,3,4 ) are each in fluid communication with a corresponding inlet port ( 8,9,10 ) and are each in fluid communication also with one of a corresponding set of outlet ports ( 11,12,13 ), and wherein each of said set of inlet ports ( 8,9 10 ) is arranged to cooperate with a respective complementary outlet port of an adjacent like cassette when in a stack and said outlet ports ( 11,12,13 ) are each arranged to cooperate with a respective complementary inlet port of a further adjacent like cassette when in a stack.

First claim

What is claimed is:

1. A normal flow filtration cassette stackable with an adjacent normal flow filtration cassette to form a filtration cassette stack, said normal flow filtration cassette comprising: one or more inlet ports; one or more outlet ports; at least three port conduits; an inlet chamber in fluid communication at least with a first port conduit of said at least three port conduits; an outlet chamber in fluid communication at least with a second port conduit of the at least three port conduits; and a filter medium between said inlet chamber and said outlet chamber, wherein each port conduit of said at least three port conduits is in fluid communication with a corresponding inlet port of said one or more inlet ports and is in fluid communication also with a corresponding outlet port of said one or more outlet ports, and wherein each inlet port of said one or more inlet ports is arranged to cooperate with a respective complementary outlet port of the adjacent normal flow filtration cassette when in the formed filtration cassette stack and said each outlet port of said one or more outlet ports is arranged to cooperate with a respective complementary inlet port of a further adjacent normal flow filtration cassette when in the formed stack, wherein a third port conduit of the at least three port conduits is fluidly isolated from the inlet chamber and the outlet chamber.

2. The cassette according to claim 1 , wherein said each inlet port of the one ore more inlet ports is arranged as a recess in an inlet side of said cassette and said each outlet of the one or more outlet ports is arranged as a protrusion on an outlet side of said cassette.

3. The cassette according to claim 2 , wherein one of the one or more inlet ports is closed with a plug and/or one of the one or more outlet ports is closed with a cap.

4. The cassette according to claim 1 , wherein a slit opening in a wall of the first port conduit of the at least three port conduits provides fluid communication with the inlet chamber and a slit opening in a wall of the second port conduit of the at least three port conduits provides fluid communication with the outlet chamber.

5. The cassette according to claim 1 , wherein said filter medium is a sheet of filter medium and the cassette further comprises a support screen between said sheet and said outlet chamber.

6. The cassette according to claim 1 , wherein said filter medium comprises a depth filter pad.

7. The cassette according to claim 1 , wherein said one or more inlet ports and one or more outlet ports are hermetically sealed with removable sanitary film coven.

8. The cassette according to claim 1 , wherein the cassette is radiation sterilized.

9. The cassette according to claim 1 , wherein the cassette comprises four port conduits.

10. The cassette according to claim 1 , wherein the cassette rectangular.

11. The cassette according to claim 10 , wherein each port conduit of the at least three port conduits is located adjacent corners of said normal flow filtration cassette.

12. A stack comprising at least two normal flow filtration cassettes according to claim 1 , said at least two cassette comprises a first cassette and an adjacent second cassette, wherein the inlet and outlet ports of the first cassette and corresponding outlet and inlet ports of the adjacent second cassette are in mating cooperation with each other.

13. The stack according to claim 12 , wherein the first cassette comprises a first filter medium or a sheet of filter medium having a first pore size rating and the second cassette comprises a second filter medium or a sheet of filter medium with properties different from the first filter medium or sheet of filter medium.

14. The stack according to claim 13 , further comprising a third cassette, which comprises a third filter medium or sheet of filter medium with properties different from said first and second filter media or sheets of filter medium.

15. The stack according to claim 12 , wherein the first cassette comprises a first inlet port and two outlet ports, wherein a first outlet port of said outlet ports is comprised in the same port conduit as the first inlet port so as to be in open and in fluid communication with the inlet or outlet chamber of said first cassette; and wherein the adjacent second cassette comprises a second inlet port mated with first outlet port of the first cassette, the second inlet port mated with open outlet port of the first cassette and a second outlet port of the second cassette comprised in the same port conduit as the second inlet port.

16. The stack according to claim 12 , wherein the outlet chamber of the first cassette comprising a first filter medium or sheet of filter medium having a first pore size rating is in fluid-communication with the inlet chamber of the second cassette comprising a second filter medium or sheet of filter medium having a second pore size rating which is at least 10% smaller than the first pore size rating.

17. The stack according to claim 16 , wherein the fluid communication between the outlet chamber of the first cassette and the inlet chamber of the second cassette is provided via a port conduit of another cassette, which port conduit is fluidly isolated from the inlet and outlet chambers of this cassette.

18. The cassette according to claim 6 , wherein the depth filter pad comprises a fibrous depth filter pad or a porous polymer depth filter pad.

Assignees

• Ge Healthcare Bio Sciences Ab

Inventors

• Lambalot Charles
• Larsen William

Classifications

• B01D63/084

  at least one flow duct intersecting the membranes · CPC title

• C12M47/10

  Separation or concentration of fermentation products (bioreactors combined with means for distillation or extraction of liquid fuel C12M43/02) · CPC title

• C12M23/42

  Integrated assemblies, e.g. cassettes or cartridges · CPC title

• C12M47/12 Primary

  Purification (C12M47/04 takes precedence) · CPC title

• B01D29/56 Primary

  in series connection · CPC title