Lubricant coating for medical container

Patent metadata

Field	Value
Publication number	US-10066182-B2
Application number	US-201314399192-A
Country	US
Kind code	B2
Filing date	May 7, 2013
Priority date	May 7, 2012
Publication date	Sep 4, 2018
Grant date	Sep 4, 2018

Abstract

The invention relates to a lubricant coating for a medical container comprising a cross-linked lubricant composition comprising a mixture of non-reactive silicone with reactive silicone, characterized in that the reactive silicone comprises a mixture of vinyl-based silicone and acrylate-based silicone. The invention further relates to a lubricant composition usable as an intermediate product in the fabrication of a lubricant coating. The invention further relates to a medical container comprising a barrel and a stopper in gliding engagement within the barrel, comprising such a lubricant coating. The invention also relates to a process of manufacturing a medical container comprising a barrel and a stopper in gliding engagement within the barrel including depositing a lubricant composition on the inner surface of the barrel and/or on the stopper, and irradiating the coated barrel and/or stopper so as to cross-link the lubricant composition to form a lubricant coating.

First claim

The invention claimed is:

1. A medical container comprising a barrel having an inner surface and a stopper in gliding engagement with at least a portion of the inner surface of the barrel, wherein at least one of the barrel and the stopper are at least partially coated with a cross-linked lubricant composition comprising:
a mixture of non-reactive silicone with reactive silicone, wherein the reactive silicone comprises a mixture of vinyl-based silicone and acrylate-based silicone,
wherein the vinyl-based silicone is 10 weight % and the acrylate-based silicone is 3 weight % relative to the total weight of the lubricant composition.

2. The medical container of claim 1 , wherein the lubricant composition has a coating thickness of at least 350 nm.

3. The medical container of claim 1 , wherein the lubricant coating covers up to 90% of the inner surface of the barrel.

4. The medical container of claim 1 , wherein the barrel is formed of plastic.

5. The medical container of claim 1 , wherein the non-reactive silicone is between 80 and 90 weight % relative to the total weight of the lubricant composition.

6. The medical container of claim 1 , wherein the non-reactive silicone is poly-(dimethylsiloxane).

7. The medical container of claim 1 , wherein the vinyl-based silicone comprises a trimethylsilyl-terminated vinylmethylsiloxane-dimethylsiloxane copolymer.

8. The medical container of claim 1 , wherein the acrylate-based silicone comprises a trimethylsilyl-terminated acryloxypropylmethylsiloxane-dimethylsiloxane copolymer.

9. The medical container of claim 1 , wherein the lubricant composition has a gel structure, the gel structure comprising a three-dimensional solid structure formed of cross-linked reactive functional groups of the reactive silicone and a liquid phase comprising non-reactive silicone, the liquid phase being retained within the three-dimensional solid structure.

10. The medical container of claim 1 , wherein the lubricant composition has a gel structure comprising a gel fraction of between 25 and 55 weight %.

11. The medical container of claim 1 , wherein the lubricant composition has a shear viscosity between 500 and 2,000 Pa·s for a shear rate of 0.1 rad/s at 25° C.

12. The medical container of claim 1 , wherein the lubricant composition has a phase angle between 20° and 40° for a shear rate of 0.1 rad/s at 25° C.

Assignees

• Becton Dickinson France

Inventors

• Santucci-Aribert Virginie
• Rossito Emanuela

Classifications

• C10N2030/06

  Oiliness; Film-strength; Anti-wear; Resistance to extreme pressure · CPC title

• B65D2539/008

  with coatings or coverings · CPC title

• C10N2050/10

  semi-solid; greasy · CPC title

• A61M5/3129

  Syringe barrels (A61M5/3205 and A61M5/50 take precedence) · CPC title

• A61L29/06

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title