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Human hepatoma cell line HLCZ01 and uses thereof
US9989520B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9989520-B2 |
| Application number | US-201314414886-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 10, 2013 |
| Priority date | Feb 1, 2013 |
| Publication date | Jun 5, 2018 |
| Grant date | Jun 5, 2018 |
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Abstract
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A human hepatoma cell line is HLCZ01 cell line which has been deposited in the China Center for Type Culture Collection (CCTCC), and having Accession (deposit) No. is CCTCC NO: C201309. The human hepatoma cell line HLCZ01 is used as a cell model supporting said hepatitis viruses infection and is used to establish an animal model for supporting virus infection, wherein said human hepatoma cell line HLCZ01 is also used for preparation, screening and evaluating anti-hepatitis virus drugs, anti-tumor drugs, and used for manufacturing artificial liver.
First claim
Opening claim text (preview).
What is claimed is: 1. A hepatoma cell line, wherein said cell line is named as a HLCZ01 cell line which is deposited in the China Center for Type Culture Collection (CCTCC) with Accession No. is CCTCC NO: C201309. 2. The hepatoma cell line, as recited in claim 1 , wherein said HLCZ01 cell line is a human hepatoma cell line HLCZ01 having 54 to 63 chromosomes, wherein said human hepatoma cell line HLCZ01 shows a phenomenon of heteromorphic chromosomes after karyotype analysis of chromosome G band, and a marker chromosome appears in a karyotype. 3. The hepatoma cell line, as recited in claim 2 , wherein said human hepatoma cell line HLCZ01 is infectable by hepatitis C virus (HCV) and hepatitis B virus (HBV). 4. The hepatoma cell line, as recited in claim 2 , wherein said human hepatoma cell line HLCZ01 comprises hepatocyte specific genes ALB and AAT. 5. The hepatoma cell line, as recited in claim 4 , wherein said hepatocyte specific genes ALB and AAT are detected by RT-PCR. 6. The hepatoma cell line, as recited in claim 4 , wherein said hepatocyte specific genes ALB and AAT are detected by a Western Blot. 7. A cell model for preparation, screening and evaluation of anti-HCV hepatitis virus drugs, which comprises a human hepatoma cell line HLCZ01 having 54 to 63 chromosomes, wherein said human hepatoma cell line HLCZ01 shows a phenomenon of heteromorphic chromosomes after karyotype analysis of chromosome G band, and a marker chromosome appears in a karyotype. 8. The cell model, as recited in claim 7 , wherein said human hepatoma cell line HLCZ01 is infectable by hepatitis C virus (HCV) and hepatitis B virus (HBV). 9. The cell model, as recited in claim 7 , wherein said human hepatoma cell line HLCZ01 comprises hepatocyte specific genes ALB and AAT. 10. The cell model, as recited in claim 9 , wherein said hepatocyte specific genes ALB and AAT are detected by RT-PCR. 11. The cell model, as recited in claim 9 , wherein said hepatocyte specific genes ALB and AAT are detected by a Western Blot.
Assignees
Inventors
Classifications
transferring nitrogenous groups (2.6) · CPC title
Tumour cells; Cancer cells · CPC title
Screening for pharmacological compounds · CPC title
Expression markers · CPC title
- G01N33/5067Primary
Liver cells · CPC title
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Frequently asked questions
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- What does patent US9989520B2 cover?
- A human hepatoma cell line is HLCZ01 cell line which has been deposited in the China Center for Type Culture Collection (CCTCC), and having Accession (deposit) No. is CCTCC NO: C201309. The human hepatoma cell line HLCZ01 is used as a cell model supporting said hepatitis viruses infection and is used to establish an animal model for supporting virus infection, wherein said human hepatoma cell l…
- Who is the assignee on this patent?
- Hunan Provincial Tumor Hospital, Univ Hunan
- What technology area does this patent fall under?
- Primary CPC classification G01N33/5067. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Jun 05 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).