Synergistic compositions
US-2017320823-A1 · Nov 9, 2017 · US
Bacterial topoisomerase inhibitors and use thereof
US9988341B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9988341-B2 |
| Application number | US-201715491679-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 19, 2017 |
| Priority date | Apr 19, 2016 |
| Publication date | Jun 5, 2018 |
| Grant date | Jun 5, 2018 |
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- Title
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- Abstract
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Abstract
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The present invention provides novel compounds as bacterial topoisomerase inhibitors with antibacterial activity. The present invention also provides pharmaceutical compositions comprising at least one of the compounds and methods of using the compounds and pharmaceutical compositions as antibacterial agents for treating infectious diseases.
First claim
Opening claim text (preview).
We claim: 1. A compound comprising a polyamine scaffold, wherein the compound has the following general structure: wherein R 1 , R 2 , R 3 , R 4 , and R 6 are, independently, hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, alkenyl, alkynyl, acyl, haloalkyl, thiol, amino, alkylamino, hydroxyl, hydroxylalkyl, or —COOH; R 5 is alkyl, amino, or substituted alkyl, the substituted group being selected from amino, naphthyl, alkylamino and guanidine; and R 7 is a substituted alkyl, the substituted group being naphthyl. 2. The compound according to claim 1 , wherein R 1 , R 2 , R 4 , and R 6 , are hydrogen; and R 3 is hydrogen, alkyl, amino, or substituted alkyl, the substituted group being selected from amino, naphthyl, and alkylamino. 3. The compound according to claim 1 , wherein R 7 is a substituted methyl or ethyl, the substituted group being naphthyl. 4. The compound according to claim 1 , wherein R 3 and R 5 are, independently, alkyl, amino, or substituted alkyl, the substituted group being selected from amino, naphthyl, and alkylamino. 5. The compound according to claim 1 , wherein at least one of R 3 and R 5 is a substituted alkyl, the substituted group being naphthyl. 6. The compound according to claim 5 , wherein at least one of R 3 and R 5 is a substituted methyl or ethyl, the substituted group being naphthyl. 7. The compound according to claim 1 , wherein at least one of R 3 and R 5 is a substituted alkyl, the substituted group being amino. 8. The compound according to claim 1 , wherein at least one of R 3 and R 5 is a substituted alkyl, the substituted group being alkylamino. 9. The compound according to claim 1 , wherein R 5 is a substituted alkyl, the substituted group being guanidine. 10. The compound according to claim 1 , which is compound 2471-12, 2471-24, 2471-36, 2471-80, 2580-3, 2580-15, 2580-18, 2580-24, 2580-27, or 2580-33. 11. A pharmaceutical composition for treating a bacterial infection comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
Assignees
Inventors
Classifications
- C07C211/30Primary
the six-membered aromatic ring being part of a condensed ring system formed by two rings · CPC title
Optical isomers · CPC title
being further substituted by nitrogen atoms not being part of nitro or nitroso groups · CPC title
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Frequently asked questions
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- What does patent US9988341B2 cover?
- The present invention provides novel compounds as bacterial topoisomerase inhibitors with antibacterial activity. The present invention also provides pharmaceutical compositions comprising at least one of the compounds and methods of using the compounds and pharmaceutical compositions as antibacterial agents for treating infectious diseases.
- Who is the assignee on this patent?
- Tse Dinh Yuk Ching, Giulianotti Marcello Angelo, Houghten Richard Allen, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C07C211/30. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jun 05 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).