Flow control devices and their use with explosive carrier gases

Patent metadata

Field	Value
Publication number	US-9983104-B2
Application number	US-201514634856-A
Country	US
Kind code	B2
Filing date	Mar 1, 2015
Priority date	Jan 18, 2011
Publication date	May 29, 2018
Grant date	May 29, 2018

Abstract

Certain embodiments described herein are directed to devices, systems and methods that are configured to control flow of an explosive carrier gas in a sampling system. In some examples, a flow control device configured to provide release of explosive carrier gas in less than an explosive amount to void space in the sampling system is described. Systems and methods using the flow control device are also disclosed.

First claim

The invention claimed is:

1. A gas chromatography system comprising:
a temperature regulated column space configured to receive a chromatography column:
a sampling system fluidically coupled to the column space and configured to provide sample to the chromatography column in the column space, the sampling system comprising a flow control device configured to provide release of explosive carrier gas provided by a carrier gas fluid line in less than an explosive amount to void space in the sampling system, in which the sampling system is configured to use hydrogen gas as the explosive carrier gas, and in which the sampling system is configured to reduce sample run time by at least 40% using the explosive carrier gas comprising the hydrogen gas when compared to sample run time using helium as a carrier gas; and
a detector fluidically coupled to the column space and configured to receive analyte from the chromatography column.

2. The gas chromatography system of claim 1 , in which the sampling system and the detector each are configured to receive gas from the same carrier gas source.

3. The gas chromatography system of claim 2 , in which the detector is configured as a flame detector.

4. The gas chromatography system of claim 3 , in which the flame detector is a flame ionization detector.

5. The gas chromatography system of claim 2 , in which the detector is configured as a plasma detector.

6. The gas chromatography system of claim 1 , in which the flow control device is configured as a sampling device comprising a longitudinal shaft and an effective inner diameter to provide release of the explosive carrier gas in less than the explosive amount to void space in the sampling system.

7. The gas chromatography system of claim 6 , in which the effective internal diameter is about 0.15 mm or less.

8. The gas chromatography system of claim 6 , in which the sampling device comprises a variable inner diameter with at least some portion comprising an effective inner diameter of about 0.15 mm or less.

9. The gas chromatography system of claim 1 , in which the flow control device is configured as an inline restrictor between a carrier gas source and the sampling system, in which the restrictor is configured to provide release of the explosive carrier gas in less than the explosive amount to void space in the sampling system.

10. The gas chromatography system of claim 1 , in which the flow control device is configured as a mass flow controller between a carrier gas source and the sampling system, in which the mass flow controller is operative to control the flow rate of explosive carrier gas to provide release of the explosive carrier gas in less than the explosive amount to void space in the sampling system.

11. The gas chromatography system of claim 1 , further comprising a fluid transfer line comprising an inner diameter effective to transfer sample to the chromatography column from the sampling system without release of an explosive amount of the explosive carrier gas to void space in the sampling system.

12. A gas chromatography system comprising:
a temperature regulated column space configured to receive a chromatography column:
a sampling system fluidically coupled to the column space and configured to provide sample to the chromatography column in the column space, the sampling system comprising a flow control device configured to provide release of explosive carrier gas provided by a carrier gas fluid line in less than an explosive amount to void space in the sampling system;
a fluid transfer line comprising an inner diameter effective to transfer sample to the chromatography column from the sampling system without release of an explosive amount of the explosive carrier gas to void space in the sampling system, in which the effective inner diameter of the transfer line provides a pressure 15-20 psig at an explosive carrier gas flow rate of 15-20 mL/minute; and
a detector fluidically coupled to the column space and configured to receive analyte from the chromatography column.

13. The gas chromatography system of claim 12 , in which the effective inner diameter of the transfer line is about 0.2 mm to about 0.25 mm.

14. The gas chromatography system of claim 12 , further comprising at least one active component in the void space of the sampling system, the at least one active component capable of causing explosion of the explosive carrier gas when released in an explosive amount.

15. The gas chromatography system of claim 12 further comprising an explosive carrier gas vent fluidically coupled to the sampling system, the vent configured to provide release of explosive carrier gas from void space in the sampling system to the atmosphere.

16. A method of facilitating use of an explosive carrier gas in a chromatography instrument, the method comprising providing a flow control device configured to provide release of explosive hydrogen carrier gas provided by a carrier gas fluid line in less than an explosive amount to void space in a sampling system, in which the chromatography instrument is configured to reduce sample run time by at least 40% using the hydrogen carrier gas when compared to sample run time using helium as a carrier gas.

17. The method of claim 16 , further comprising configuring the flow control device as a sampling device comprising a longitudinal shaft and an effective inner diameter to provide release of the explosive carrier gas in less than the explosive amount to void space in the sampling system.

18. The method of claim 17 , further comprising configuring the effective inner diameter to be about 0.15 mm or less.

19. The method of claim 16 , further comprising configuring the flow control device as an inline restrictor for insertion between a carrier gas source and a sampling assembly, in which the restrictor is configured to provide release of the explosive carrier gas in less than the explosive amount to void space in the sampling system.

20. The method of claim 16 , further comprising configuring the flow control device as a mass flow controller for insertion between a carrier gas source and a sampling assembly, in which the mass flow controller is operative to control the flow rate of explosive carrier gas to provide release of the explosive carrier gas in less than the explosive amount to void space in the sampling system.

Assignees

• Tipler Andrew
• Perkinelmer Health Sci Inc

Inventors

• Tipler Andrew

Classifications

• G01N27/626

  using heat to ionise a gas · CPC title

• G01N2001/2229

  Headspace sampling, i.e. vapour over liquid · CPC title

• G01N1/2226 Primary

  Sampling from a closed space, e.g. food package, head space · CPC title

• G01N2030/025

  Gas chromatography · CPC title

• G01N30/28

  Control of physical parameters of the fluid carrier · CPC title