Methods, devices, and systems for controlling the rate of gas depressurization within a vial containing a gas sample

Patent metadata

Field	Value
Publication number	US-9429499-B2
Application number	US-91560010-A
Country	US
Kind code	B2
Filing date	Oct 29, 2010
Priority date	Oct 29, 2010
Publication date	Aug 30, 2016
Grant date	Aug 30, 2016

Abstract

The present invention relates to methods and systems for controlling depressurization of a vial containing a gas sample. The disclosed systems and methods are employed during sampling and/or analysis of the gas sample. One exemplary method for controlling depressurization of a vial containing a gas sample includes establishing fluid communication between a sample loop of a head space sampling device and the head space of the vial. A sample gas pressure is established within the head space of the vial. The sample loop is connected in fluid communication with a lower pressure environment through a ventilation pathway. A ventilation valve within the ventilation pathway is used to vent gas from the vial through the sample loop to the lower pressure environment at a predetermined rate. Devices and systems for depressurizing a vial containing a gas sample at a predetermined rate are also disclosed.

First claim

What is claimed is:

1. A method for controlling a rate of gas depressurization within a vial having a head space to be sampled by a head space sampling device, said head space sampling device having a ventilation pathway connectable in fluid communication with a lower pressure environment, and a sample loop connectable between and in fluid communication with said head space and said ventilation pathway, said method comprising:
establishing fluid communication between said sample loop and said head space,
establishing a sample gas pressure within said head space, said sample gas pressure being greater than the pressure in said lower pressure environment;
connecting said sample loop in fluid communication with said lower pressure environment through said ventilation pathway; and
venting gas from said head space through said sample loop to said lower pressure environment, thereby allowing sample gas to flow from said head space to said sample loop, to provide a predetermined rate of gas depressurization within the head space and sample loop,
wherein the pressure of sample gas in said head space and sample loop is directly controlled by said predetermined rate of gas depressurization to a predetermined head space pressure setpoint less than the initial sample gas pressure.

2. The method according, to claim 1 , further comprising: heating said vial to produce a vapor in said head space containing said gas sample.

3. The method according to claim 1 , wherein said head space sampling device further comprises a pressurization gas conduit having an inlet for receiving a pressurization gas, said pressurization gas conduit being connectable in fluid communication with said head space of said vial, and wherein establishing the sample gas pressure within said head space comprises:
establishing fluid communication between said head space and said pressurization gas conduit; and
pressurizing said pressurization gas conduit with said pressurization gas.

4. The method according to claim 1 , wherein said vial comprises a septum, and wherein establishing fluid communication between said sample loop and said head space comprises penetrating said septum with a needle having a bore that is in fluid communication with the sample loop.

5. The method according to claim 1 , wherein said predetermined rate of depressurization of said head space to said lower pressure environment ranges from above 0 kPa/sec. to about 25 kPa/sec.

6. The method according to claim 1 , wherein said predetermined rate of depressurization of said head space to said lower pressure environment is about 2.3 kPa/sec.

7. The method according to claim 1 , wherein said head space sampling device is connectable to a head space analyzer and a carrier gas conduit with an inlet for receiving a carrier gas, and wherein said sample loop is connectable to allow fluid communication either between said head space and said ventilation pathway or between said carrier gas conduit and said head space analyzer, said method further comprising:
establishing fluid communication between said carrier gas conduit, said sample loop, and said head space analyzer; and
pressurizing said carrier gas conduit with said carrier gas such that at least portion of said sample gas within said sample loop is forced into said head space analyzer.

8. The method according to claim 7 , wherein establishing fluid communication between said carrier gas conduit, sample loop, and said head space analyzer occurs during venting of gas from said head space through said sample loop to said lower pressure environment at said predetermined rate of depressurization.

9. The method according to claim 7 , farther comprising:
monitoring the gas pressure within said head space; and
allowing, said gas pressure within said head space to substantially stabilize prior to establishing fluid communication between said carrier gas conduit, said sample loop, and said head space analyzer.

10. The method according to claim 1 , wherein said predetermined rate of depressurization of said head space to said lower pressure environment corresponds to a substantially exponential decrease of the gas pressure within said head space.

11. A method for controlling a rate of gas depressurization within a vial having a head space to be sampled by a head space sampling device, said head space sampling device having a ventilation pathway connectable in fluid communication with a lower pressure environment, and a sample loop connectable between and in fluid communication with said head space and said ventilation pathway, said method comprising:
establishing fluid communication between said sample loop and said head space;
establishing a sample gas pressure within said head space, said sample gas pressure being greater than the pressure in said lower pressure environment;
connecting said sample loop in fluid communication with said lower pressure environment through said ventilation pathway;
venting gas from said head space through said sample loop to said lower pressure environment, thereby allowing sample gas to flow from said head space to said sample loop, to provide a predetermined rate of gas depressurization within the head space and sample loop; and
monitoring the sample gas pressure within said head space, wherein gas is vented from said head space through the sample loop to said lower pressure environment, such that said sample gas pressure within said head space gradually decreases to a predetermined pressure setpoint,
wherein the pressure of sample gas in said head space and sample loop is directly controlled by said predetermined rate of gas depressurization and said predetermined pressure setpoint is less than the initial sample gas pressure.

12. The method according to claim 11 , wherein said predetermined pressure setpoint ranges from about 100 to about 800 kPa.

13. The method according to claim 11 , wherein said predetermined pressure setpoint is about 170 kPa.

14. A method for controlling a rate of gas depressurization within a vial having a head space to be sampled by a head space sampling device, said head space sampling device having a ventilation pathway connectable in fluid communication with a lower pressure environment, and a sample loop connectable between and in fluid communication with said head space and said ventilation pathway, said method comprising:
establishing fluid communication between said sample loop and said head space;
establishing a sample gas pressure within said head space, said sample gas pressure being greater than the pressure in said lower pressure environment;
connecting said sample loop in fluid communication with said lower pressure environment through said ventilation pathway; and
venting gas from said head space through said sample loop to said lower pressure environment, thereby allowing sample gas to flow from said head space to said sample loop, to provide a predetermined rate of gas depressurization within the head space and sample loop,
wherein the pressure of sample gas in said head space and sample loop is directly controlled by said predetermined rate of gas depressurization to a predetermined head space pressure setpoint less than the initial sample gas pressure,
wherein said predetermined rate of gas depressurization is substantially linear.

Assignees

• Bushey Jared M
• Henderson Robert C
• Wilson William H
• Agilent Technologies Inc

Inventors

• Bushey Jared M
• Henderson Robert C
• Wilson William H

Classifications

• G01N2001/2238

  the gas being compressed or pressurized · CPC title

• G01N1/2226 Primary

  Sampling from a closed space, e.g. food package, head space · CPC title

• Y10T137/7761

  Electrically actuated valve · CPC title

• Y10T137/0379

  By fluid pressure · CPC title