Method of producing a composition containing caseinomacropeptide

Patent metadata

Field	Value
Publication number	US-9955705-B2
Application number	US-201314442648-A
Country	US
Kind code	B2
Filing date	Nov 15, 2013
Priority date	Nov 15, 2012
Publication date	May 1, 2018
Grant date	May 1, 2018

Abstract

The present invention pertains to a method of producing caseinomacropeptide (CMP)-containing compositions in high yield and having a very low content of phenylalanine (Phe). More specifically, the method involves subjecting a whey derived feed to a combination of ultrafiltration and subsequent cation exchange.

First claim

The invention claimed is:

1. A method of producing a caseinomacropeptide-containing composition having a low content of phenylalanine (Phe), said composition having a range of 0.1%-0.5% (w/w) Phe relative to the total amount of protein of the composition, the method comprising the steps of:
a) providing a whey-derived feed comprising caseinomacropeptide (CMP) and at least one additional protein, said whey-derived feed having a pH in the range of 1-4,
b) subjecting said whey-derived feed to ultrafiltration using an ultrafiltration filter (UF) allowing the passage of monomeric CMP, thereby providing a UF permeate and a UF retentate, which UF permeate is enriched with respect to CMP,
c) contacting a first composition derived from said UF permeate with a cation exchange material, and
d) collecting the fraction of the first composition which is not bound to the cation exchange material, thereby obtaining the CMP-containing composition.

2. The method according to claim 1 , wherein the whey-derived feed is derived from cheese whey or a concentrate thereof.

3. The method according to claim 1 , wherein the whey-derived feed comprises whey obtained from rennet coagulated casein or caseinate, or a concentrate thereof.

4. The method according to claim 1 , wherein the whey-derived feed contains a total amount of CMP of at least 1% (w/w) relative to the total amount of protein.

5. The method according to claim 1 , wherein the at least one additional protein is selected from the group consisting of immunoglobulin G, immunoglobulin M, bovine serum albumin (BSA), beta-lactoglobulin, alpha-lactalbumin, beta casein, casein derived peptides, milk fat globule membrane (MFGM) proteins, and a combination thereof.

6. The method according to claim 1 , wherein the whey-derived feed contains a total amount of protein having a range of 0.2%-20% (w/w) relative to the weight of the whey-derived feed.

7. The method according to claim 1 , wherein the ultrafiltration filter has a nominal molecular weight cut-off in the range of 5-300 kDa.

8. The method according to claim 1 , wherein the first composition contains a total amount of CMP having a range of 55%-95% (w/w) relative to the total amount of protein.

9. The method according to claim 1 , wherein the first composition contains a total amount of protein of at least 0.1% (w/w).

10. The method according to claim 1 , wherein the first composition has a pH in the range of pH 2-5.

11. The method according to claim 1 , wherein the first composition has a conductivity in the range of 1-8 mS/cm.

12. The method according to claim 1 , further comprising concentrating the collected fraction.

13. The method according to claim 1 , further comprising spray-drying the collected fraction.

Assignees

• Arla Foods Amba

Inventors

• Christensen Jesper
• Holst Hans Henrik

Classifications

• A23C9/1425 Primary

  by ultrafiltration, microfiltration or diafiltration of whey, e.g. treatment of the UF permeate · CPC title

• A23C2210/206

  Membrane filtration of a permeate obtained by ultrafiltration, nanofiltration or microfiltration · CPC title

• A23J1/20

  from milk, e.g. casein (curds or cheese A23C); from whey · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23J1/205

  from whey, e.g. lactalbumine · CPC title