Peptides for promoting angiogenesis and use thereof

Patent metadata

Field	Value
Publication number	US-9938320-B2
Application number	US-201715434309-A
Country	US
Kind code	B2
Filing date	Feb 16, 2017
Priority date	Mar 26, 2010
Publication date	Apr 10, 2018
Grant date	Apr 10, 2018

Abstract

The present invention relates to a peptide promoting angiogenesis and novel use thereof. More particularly, the invention relates to peptides promoting angiogenesis, and the use of the peptide for promoting angiogenesis and preventing or treating angiogenesis-related disease. The peptide of the present invention have an excellent effect on promoting angiogenesis. Accordingly, it is useful for preventing or treating angiogenesis-related disease and for preparing regeneration of skin flap, wound and burn healing, implantation of artificial skin and preparation of blood vessels for transplantation.

First claim

The invention claimed is:

1. An isolated peptide consisting of the amino acid sequence set forth in SEQ ID NO: 4, optionally wherein the C-terminal end of the peptide is amidated.

2. The isolated peptide of claim 1 , wherein the C-terminal end of the peptide is amidated.

3. A composition comprising the isolated peptide of claim 1 .

4. A composition comprising the isolated peptide of claim 2 .

5. The isolated peptide of claim 1 which consists of the amino acid sequence set forth in SEQ ID NO: 4.

6. A composition comprising the isolated peptide of claim 5 .

7. A method for promoting angiogenesis by administering an effective amount of the isolated peptide of claim 1 to a subject in need thereof.

8. The method of claim 7 wherein the subject in need thereof has an angiogenesis-related disease selected from the group consisting of diabetic foot ulcer, ischemic cardiomyopathy, ischemic brain disease, acute posterior ischemia, chronic ulcer and ischemia.

Assignees

• Industry Academic Cooperation Foundation Sookmyung Womens Univ
• Il Yang Pharm Co Ltd
• Samsung Life Public Welfare Foundation

Inventors

• Cho Dae Ho
• Bang Sa Ik
• Park Jeong Min
• Yoon Sun Young
• Kim Sang Yoon
• Lee Ha Rum
• Park Yoo Rim
• Son Juah

Classifications

• A61P9/12

  Antihypertensives · CPC title

• A61P9/04

  Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P27/06

  Antiglaucoma agents or miotics · CPC title