Benzamides
US-9498475-B2 · Nov 22, 2016 · US
US9938262B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9938262-B2 |
| Application number | US-201615283938-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 3, 2016 |
| Priority date | Jul 18, 2011 |
| Publication date | Apr 10, 2018 |
| Grant date | Apr 10, 2018 |
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Novel benzamide derivatives of formula (I) wherein W 1 , W 2 , R 1 to R 7 , R 6 , X and Y have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
Opening claim text (preview).
The invention claimed is: 1. A compound selected from: or a physiologically acceptable salt thereof. 2. A method for treating fertility disorders, wherein at least one compound of claim 1 is administered to a mammal in need of such treatment. 3. A method for agonizing an FSH receptor, comprising contacting the FSH receptor with at least one compound of claim 1 under conditions such that the FSH receptor is agonized. 4. A pharmaceutical composition comprising at least one compound according to claim 1 or a physiologically acceptable salt thereof. 5. The pharmaceutical composition according to claim 4 , comprising pharmaceutically tolerable adjuvants for oral administration. 6. The pharmaceutical composition according to claim 4 , comprising at least a second active pharmaceutical ingredient.
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis · CPC title
linked by a chain containing hetero atoms as chain links · CPC title
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone · CPC title
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems · CPC title
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