Inhibitors of tyk2
US-2024425484-A1 · Dec 26, 2024 · US
Compounds and methods for treating mammalian gastrointestinal microbial infections
US8969342B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8969342-B2 |
| Application number | US-201013257418-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 22, 2010 |
| Priority date | Mar 20, 2009 |
| Publication date | Mar 3, 2015 |
| Grant date | Mar 3, 2015 |
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Abstract
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Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
First claim
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We claim: 1. A compound, or a pharmaceutically acceptable salt thereof, represented by Formula XII: wherein, independently for each occurrence, m is 0, 1, or 2; R 2 is hydrogen or alkyl;…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8969342B2 cover?
- Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of …
- Who is the assignee on this patent?
- Hedstrom Lizbeth K, Cuny Gregory D, Gollapalli Deviprasad R, and 6 more
- What technology area does this patent fall under?
- Primary CPC classification C07D401/12. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 03 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).