Chemical tools for imaging phospholipase D activity
US-11198898-B2 · Dec 14, 2021 · US
Antibiotic
US9920025B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9920025-B2 |
| Application number | US-201515329758-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 30, 2015 |
| Priority date | Jul 30, 2014 |
| Publication date | Mar 20, 2018 |
| Grant date | Mar 20, 2018 |
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- Title
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Abstract
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The present invention relates to novel compounds, comprising an 8- or 9-membered cyclic structure, wherein an (E)-1,4-dioxo-but-2-ene moiety is embedded in said cyclic structure and to pharmaceutical compositions comprising these compounds. The compounds may be used as medicaments, in particular as medicaments for treating and preventing microbial infections, such as infections by multidrug resistant and/or Gram-positive bacteria. The invention further relates to fermentation processes wherein fungi of the genus Ulocladium are used for producing the novel compounds.
First claim
Opening claim text (preview).
The invention claimed is: 1. A compound comprising a lactone ring comprising a single (E)-7-hydroxy-4-oxo-hept-2-enoic acid. 2. The compound according to claim 1 , which is (E)-7-hydroxy-4-oxo-oct-2-enoic acid lactone. 3. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier. 4. A method of treating a microbial infection comprising administering to a subject in need thereof a compound comprising a lactone ring comprising a single (E)-7-hydroxy-4-oxo-hept-2-enoic acid. 5. The method according to claim 4 , wherein the microbial infection is a bacterial infection. 6. The method according to claim 5 , wherein the bacterial infection is an infection by a multidrug resistant bacterium. 7. The method according to claim 5 , wherein the bacterial infection is an infection by a Gram-positive bacterium. 8. The method according to claim 7 , wherein the Gram-positive bacterium is a methicillin-resistant Staphylococcus. 9. The method according to claim 8 , wherein the Gram-positive bacterium is a methicillin-resistant Staphylococcus aureus.
Assignees
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Classifications
Antibacterial agents · CPC title
Drugs for skeletal disorders · CPC title
- C07D313/18Primary
not condensed with other rings · CPC title
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Frequently asked questions
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- What does patent US9920025B2 cover?
- The present invention relates to novel compounds, comprising an 8- or 9-membered cyclic structure, wherein an (E)-1,4-dioxo-but-2-ene moiety is embedded in said cyclic structure and to pharmaceutical compositions comprising these compounds. The compounds may be used as medicaments, in particular as medicaments for treating and preventing microbial infections, such as infections by multidrug res…
- Who is the assignee on this patent?
- Koninklijke Nederlandse Akademie Van Wetenschappen
- What technology area does this patent fall under?
- Primary CPC classification C07D313/18. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 20 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).