Milled bone graft materials and methods of use

Patent metadata

Field	Value
Publication number	US-9913676-B2
Application number	US-201514941033-A
Country	US
Kind code	B2
Filing date	Nov 13, 2015
Priority date	Nov 14, 2014
Publication date	Mar 13, 2018
Grant date	Mar 13, 2018

Abstract

A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.

First claim

What is claimed is:

1. A bone material for hydration with a liquid, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass of milled and demineralized bone fiber having no binder disposed in or on the coherent mass, wherein the coherent mass is a cylinder shape and the cylinder has hydration channels on an exterior surface, the hydration channels extending along a longitudinal axis of the cylinder.

2. A bone material according to claim 1 , wherein the bone material is lyophilized.

3. A bone material of claim 2 , wherein the coherent mass of milled and lyophilized demineralized bone fibers are cartridge milled fibers having a ribbon-like shape, increased surface area and a curled portion.

4. A bone material of claim 2 , wherein the coherent mass of milled and lyophilized demineralized bone fibers comprise autograft or allograft bone.

5. A bone material according to claim 1 , wherein the milled and demineralized bone fibers are cartridge milled and have a ribbon-like shape with increased surface area compared to demineralized bone powder.

6. A bone material of claim 1 , wherein the bone fibers have a diameter from about 100 μm to about 2 mm.

7. A bone material of claim 1 , wherein the fibers have an aspect ratio of from about 50:1 to about 1000:1, from about 50:1 to about 950:1, from about 50:1 to about 750:1, from about 50:1 to about 500:1, from about 50:1 to about 250:1, from about 50:1 to about 100:1, from about 10:1 to about 50:1, or from about 5:1 to about 10:1.

8. A bone material of claim 1 , wherein the liquid comprises blood, water, saline or a combination thereof.

9. A bone material of claim 1 , wherein the liquid is mixed with the coherent mass of milled and demineralized bone fibers that are lyophilized without a binder to form moldable lyophilized demineralized bone fibers.

10. A bone material of claim 1 , wherein the coherent mass comprises a first end having a first diameter and a second end having a second diameter, the first diameter is wider than or the same size as the second diameter.

11. A bone material of claim 1 , wherein the hydration channels have a rounded inner surface.

12. A bone material of claim 1 , wherein the hydration channels have a straight inner surface.

13. A bone material for hydration with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass of milled, lyophilized and demineralized bone fibers having no binder disposed in or on the coherent mass, wherein the coherent mass is a cylinder shape and the cylinder has hydration channels on an exterior surface, the hydration channels extending along a longitudinal axis of the cylinder.

14. A bone material of claim 13 , wherein the coherent mass of cartridge milled and lyophilized demineralized bone fibers have a ribbon-like shape and increased surface area compared to demineralized bone powder.

15. A bone material of claim 14 , wherein the coherent mass of cartridge milled and lyophilized demineralized bone fibers comprise autograft or allograft bone.

16. A bone material of claim 14 , wherein the fibers have an aspect ratio of from about 50:1 to about 1000:1, from about 50:1 to about 950:1, from about 50:1 to about 750:1, from about 50:1 to about 500:1, from about 50:1 to about 250:1, from about 50:1 to about 100:1, from about 10:1 to about 50:1, or from about 5:1 to about 10:1.

17. A bone material of claim 14 , wherein the liquid is mixed with the coherent mass of cartridge milled and demineralized bone fibers that are lyophilized without a binder to form moldable lyophilized demineralized bone fibers.

Assignees

• Warsaw Orthopedic Inc

Inventors

• Schlachter Kelly W
• Shimko Daniel A
• Kalpakci Kerem N
• Vasquez Erick
• Kaes David R
• Bhattacharyya Subhabrata

Classifications

• A61F2/4601

  for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity · CPC title

• A61L27/3683

  subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment · CPC title

• A61B17/8805

  for introducing fluid filler into bone or extracting it (A61B17/7097, A61B17/8833 take precedence) · CPC title

• A61L27/3608

  Bone, e.g. demineralised bone matrix [DBM], bone powder · CPC title

• A61L27/365

  Bones · CPC title