Osteoimplant and methods for making

Patent metadata

Field	Value
Publication number	US-9486500-B2
Application number	US-69582610-A
Country	US
Kind code	B2
Filing date	Jan 28, 2010
Priority date	Jan 28, 2010
Publication date	Nov 8, 2016
Grant date	Nov 8, 2016

Abstract

An osteoimplant is disclosed and includes a plurality of partially demineralized fibers. Each fiber has an elongated, thin body having a length of about 1 centimeter to about 3 centimeters. Further, the plurality of fibers engages to establish a matrix of material. The disclosure is further directed to a method of making the above-mentioned osteoimplant.

First claim

What is claimed is:

1. An osteoimplant comprising: a plurality of partially demineralized bone fibers in a remineralized matrix material, wherein each fiber has an elongated, thin body having a length of about 1 centimeter to about 3 centimeters, wherein the plurality of partially demineralized bone fibers are chemically crosslinked with a chemical cross-linker, wherein plurality of fibers engage to establish the matrix material, the matrix material having a porous structure throughout the internal structure of the matrix having pores of about 3.0 mm to about 5.0 mm diameter, and the osteoimplant has a compression resistance of about 10 MPa, and the length of the fibers are spatially arranged in a random-orientation, and the matrix comprises collagen dispersed within an internal structure of the matrix.

2. The osteoimplant of claim 1 , wherein the partially demineralized fibers are formed from an allogenic source.

3. The osteoimplant of claim 1 , wherein the partially demineralized fibers have about 20% to about 90% of an original mineral content removed.

4. The osteoimplant of claim 1 , wherein the chemical crosslinker includes glutaraldehyde, genipin, formaldehyde, 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide/N -hydroxysuccinimide (EDC/NHS), or a combination thereof.

5. The osteoimplant of claim 1 , further comprising an osteoconductive mineral salt incorporated within the matrix material.

6. The osteoimplant of claim 5 , wherein the osteoconductive mineral salt is calcium salt.

7. The osteoimplant of claim 1 , having a degradation rate of about 20% six months after implantation.

8. The osteoimplant of claim 1 , wherein the collagen is a freeze-dried collagen.

9. The osteoimplant of claim 8 , wherein the freeze-dried collagen further comprises osteoconductive ceramic particles.

10. The osteoimplant of claim 1 , further comprising an additive.

11. The osteoimplant of claim 10 , wherein the additive comprises a radiocontrast medium, a drug, a cellular matter, a biological factor, or a combination thereof.

12. The osteoimplant of claim 11 , wherein the drug comprises an antibiotics, an analgesics, an anti-inflammatory drugs, an anti-TNF-alpha, a steroid, or a combination thereof.

13. The osteoimplant of claim 11 , wherein the biological factor comprises bone morphogenetic protein (BMP), growth differentiation factor (GDF), platelet derived growth factor (PDGF), insulin-like growth factor (IGF), LIM mineralization protein, fibroblast growth factor (FGF), osteoblast growth factor, or a combination thereof.

Assignees

• Mckay William F
• Warsaw Orthopedic Inc

Inventors

• Mckay William F

Classifications

• A61L2300/402

  Anaestetics, analgesics, e.g. lidocaine · CPC title

• A61K38/1875 Primary

  Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor · CPC title

• A61F2002/4649

  Bone graft or bone dowel harvest sites · CPC title

• A61F2002/4495

  having a fabric structure, e.g. made from wires or fibres · CPC title

• A61L2300/41

  Anti-inflammatory agents, e.g. NSAIDs · CPC title