Characterizing liquids using magnetic discs

Patent metadata

Field	Value
Publication number	US-9903860-B2
Application number	US-201515314297-A
Country	US
Kind code	B2
Filing date	May 28, 2015
Priority date	May 29, 2014
Publication date	Feb 27, 2018
Grant date	Feb 27, 2018

Abstract

The present disclosure is directed towards characterizing liquids through the use of magnetic discs that rotate in response to dynamic magnetic fields. In some embodiments, a light beam is transmitted into the liquid while the magnetic discs rotate, and one or more parameters a light beam signal associated with the transmitted light beam are identified. Various characteristics of the liquid may be detected based on the one or more parameters of the light beam signal.

First claim

Therefore, the following is claimed:

1. A system, comprising:
a magnetic field generator to expose a liquid to a dynamic magnetic field, wherein a plurality of magnetic discs are suspended in the liquid, wherein the dynamic magnetic field causes the plurality of magnetic discs to rotate in the liquid;
a light source to transmit a light beam into the liquid, wherein the light beam transmitted into the liquid is responsive to the plurality of magnetic discs being rotated in the liquid;
a light sensor to generate a light beam signal based on a detected portion of the light beam from the liquid; and
at least one computing device to:
detect at least one parameter of the light beam signal, wherein the at least one parameter comprises a phase difference between the dynamic magnetic field and the light beam signal; and
detect a characteristic of the liquid based on the at least one parameter of the light beam signal.

2. The system of claim 1 , wherein the detected portion of the light beam is reflected by the plurality of magnetic discs in the liquid.

3. The system of claim 1 , wherein the detected portion of the light beam is transmitted through the liquid.

4. The system of claim 1 , wherein the characteristic comprises a viscosity.

5. The system of claim 1 , wherein the characteristic comprises a presence of an agent.

6. The system of claim 1 , wherein at least a subset of the plurality of magnetic discs comprise a targeting material having an affinity for an agent.

7. The system of claim 1 , wherein the dynamic magnetic field is a rotating magnetic field having a substantially constant magnitude.

8. The system of claim 1 , wherein the dynamic magnetic field is a rotating magnetic field, wherein a magnitude of the dynamic magnetic field is adjusted while a frequency of the dynamic magnetic field is substantially constant.

9. The system of claim 1 , wherein the dynamic magnetic field is a rotating magnetic field, wherein a frequency of the dynamic magnetic field is adjusted while a magnitude of the dynamic magnetic field is substantially constant.

10. The system of claim 1 , wherein the at least one parameter further comprises a change in amplitude of an intensity of the light beam signal.

11. The system of claim 1 , wherein at least one of the magnetic discs has a diameter of about 1 micrometer.

12. The system of claim 1 , wherein at least one of the magnetic discs has a thickness of about 50 nanometers.

13. The system of claim 1 , wherein the magnetic field generator comprises a plurality of coils.

14. The system of claim 13 , wherein the plurality of coils forms at least one of a Helmholtz coil pair, a solenoid, or any combination thereof.

15. The system of claim 1 , wherein the magnetic field generator comprises a plurality of Helmholtz coil pairs.

16. The system of claim 1 , wherein the magnetic field generator comprises at least one permanent magnet.

17. The system of claim 1 , wherein the plurality of magnetic discs comprises a uniform magnetic material.

18. The system of claim 1 , wherein the plurality of magnetic discs have an aspect ratio (diameter/thickness) of at least 10.

19. A method for detecting a characteristic of a liquid, comprising:
exposing the liquid to a dynamic magnetic field, wherein a plurality of magnetic discs are suspended in the liquid, wherein the dynamic magnetic field causes the plurality of magnetic discs to rotate in the liquid;
transmitting a light beam into the liquid, wherein the light beam transmitted into the liquid is responsive to the plurality of magnetic discs being rotated in the liquid;
obtaining, using at least one computing device, a light beam signal that corresponds to a detected portion of the light beam;
detecting, using the at least one computing device, at least one parameter of the light beam signal, wherein the at least one parameter comprises a phase difference between the dynamic magnetic field and the light beam signal; and
detecting, using the at least one computing device, the characteristic of the liquid based on the at least one parameter of the light beam signal.

20. The method of claim 19 , wherein the characteristic comprises a viscosity.

21. The method of claim 19 , wherein the characteristic comprises a presence of an agent.

22. The method of claim 19 , wherein the at least one parameter further comprises a change in amplitude of an intensity of the light beam signal.

23. The method of claim 19 , wherein the dynamic magnetic field rotates relative to a container for the liquid.

24. The method of claim 19 , further comprising adjusting a frequency of the dynamic magnetic field over a frequency range; and
wherein determining the at least one parameter comprises recording the light beam signal as the frequency of the dynamic field is adjusted.

25. The method of claim 24 , wherein a magnitude of the dynamic magnetic field is substantially constant as the frequency is adjusted over the frequency range.

26. The method of claim 19 , further comprising adjusting a magnitude of the dynamic magnetic field over a magnitude range while a frequency of the dynamic magnetic field is substantially constant; and
wherein determining the at least one parameter comprises recording the light beam signal as the magnitude of the dynamic magnetic field is adjusted.

27. The method of claim 19 , wherein at least one of the magnetic discs has a diameter of about 0.1 micrometers to about 5 micrometers.

28. The method of claim 19 , wherein at least one of the magnetic discs has a thickness of about 10 nanometers to about 500 nanometers.

29. The method of claim 19 , wherein the magnetic discs include a targeting material having an affinity of an agent.

30. The method of claim 29 , wherein the agent comprises at least one of a cell, a tissue, a protein, DNA, RNA, an antibody, an antigen, a predefined compound, or any combination thereof.

31. The method of claim 19 , wherein the plurality of magnetic discs comprises a uniform magnetic material.

32. The method of claim 19 , wherein the plurality of magnetic discs have a respective diameter within 0.1 micrometer to 5 micrometers, and a respective thickness within 10 nanometers to 500 nanometers.

33. A method for detecting a presence of an agent in a liquid, comprising:
exposing the liquid to a dynamic magnetic field, wherein a plurality of magnetic discs are suspended in the liquid, wherein the dynamic magnetic field causes the plurality of magnetic discs to rotate in the liquid, wherein at least a subset of the plurality of magnetic discs comprise a targeting material having an affinity for the agent;
transmitting a light beam into the liquid, wherein the light beam transmitted into the liquid is responsive to the plurality of magnetic discs being rotated in the liquid;
obtaining, using at least one computing device, a light beam signal that corresponds to a detected portion of the light beam;
detecting, using the at least one computing device, at least one parameter of the light beam signal, wherein the at least one parameter comprises a phase difference between the dynamic magnetic field and the light beam signal; and
detecting, using the at least one computing device, whether the agent is present in the liquid based on the at least one parameter of the light

Assignees

• Univ Florida
• Univ Florida

Inventors

• Arnold David P
• Garraud Nicolas

Classifications

• G01N33/5434 Primary

  using magnetic particle immunoreagent carriers which constitute new materials per se · CPC title

• G01N2021/1727

  Magnetomodulation · CPC title

• G01N27/74

  of fluids (G01N24/00 takes precedence) · CPC title

• G01N21/1717

  with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance · CPC title

• G01R33/1269

  of molecules labeled with magnetic beads (magnetic particles for bio assay G01N33/54326) · CPC title