Carrier polymer particle, process for producing the same, magnetic particle for specific trapping, and process for producing the same

Patent metadata

Field	Value
Publication number	US-9447232-B2
Application number	US-201313763236-A
Country	US
Kind code	B2
Filing date	Feb 8, 2013
Priority date	May 20, 2005
Publication date	Sep 20, 2016
Grant date	Sep 20, 2016

Abstract

A process for producing carrier polymer particles comprising covering the surface of organic polymer particles having a particle diameter of 0.1 to 20 micrometers with a saccharide by chemically bonding the organic polymers and the saccharide.

First claim

The invention claimed is:

1. A process for producing carrier polymer particles, the process comprising:
reacting an organic polymer particle precursor with a diamine to form organic polymer particles comprising a first functional group; then
reacting the first functional group of the organic polymer particles with a second functional group of a saccharide, thereby covering a surface of the organic polymer particles with the saccharide to form surface-covered organic polymer particles; and then
chemically bonding a probe for specifically trapping a target material to the saccharide of the surface-covered organic polymer particles,
to form carrier polymer particles,
wherein the organic polymer particles have a particle diameter of 0.1 to 20 micrometers.

2. The process according to claim 1 , wherein the first functional group is at least one selected from the group consisting of a carboxyl group, an epoxy group, an amino group, and a tosyl group.

3. The process of claim 1 , further comprising:
extracting saccharide physically adsorbed on the surface of the surface-covered organic polymer particles by treating the surface-covered organic polymer particles with a basic solution.

4. The process according to claim 1 , wherein the saccharide is a polysaccharide.

5. The process according to claim 1 , wherein the chemical bonding of the probe to the saccharide forms at least one amide bond.

6. The process according to claim 1 , wherein the first functional group is an amino group.

7. The process of claim 1 , wherein the organic polymer particles are magnetic particles.

8. The process of claim 1 , wherein the second functional group is a carboxymethyl group.

Assignees

• Jsr Corp

Inventors

• Takahashi Masayuki
• Fukuta Tetsuo
• Kasai Kiyoshi
• Ogawa Toshihiro
• Katayose Satoshi
• Tamori Kouji
• Yamada Kinji

Classifications

• C08G63/91 Primary

  Polymers modified by chemical after-treatment · CPC title

• G01N33/54353

  with ligand attached to the carrier via a chemical coupling agent (coatings G01N33/54393) · CPC title

• Y10T428/2998

  including synthetic resin or polymer · CPC title

• B32B5/16

  characterised by features of a layer formed of particles, e.g. chips, powder {or granules (layer formed of natural mineral particles B32B19/00; layer being formed of wood fibres, chips or particles B32B21/02)} · CPC title

• G01N33/5434 Primary

  using magnetic particle immunoreagent carriers which constitute new materials per se · CPC title