Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
US-2022055975-A1 · Feb 24, 2022 · US
US9902747B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9902747-B2 |
| Application number | US-201615541736-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 9, 2016 |
| Priority date | Feb 17, 2015 |
| Publication date | Feb 27, 2018 |
| Grant date | Feb 27, 2018 |
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The present invention relates to a novel phosphite compound represented by the formula (I): wherein R 1 , R 2 , R 3 and R 4 each independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 5 to 8 carbon atoms, an alkylcycloalkyl group having 6 to 12 carbon atoms, an aralkyl group having 7 to 12 carbon atoms, or an aryl group having 6 to 12 carbon atoms, a process for producing the same, and uses thereof as a stabilizer for an organic material.
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The invention claimed is: 1. A phosphite compound represented by the formula (I) wherein R 1 , R 2 , R 3 and R 4 each independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 5 to 8 carbon atoms, an alkyl cycloalkyl group having 6 to 12 carbon atoms, an aralkyl group having 7 to 12 carbon atoms or an aryl group having 6 to 12 carbon atoms. 2. A hydroxy compound represented by the formula (II) wherein R 3 and R 4 each independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 5 to 8 carbon atoms, an alkyl cycloalkyl group having 6 to 12 carbon atoms, an aralkyl group having 7 to 12 carbon atoms or an aryl group having 6 to 12 carbon atoms, provided that at least one of R 3 and R 4 is not hydrogen. 3. A method for producing the phosphite compound according to claim 1 , wherein a hydroxy compound represented by formula (II) wherein R 3 and R 4 each independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 5 to 8 carbon atoms, an alkyl cycloalkyl group having 6 to 12 carbon atoms, an aralkyl group having 7 to 12 carbon atoms or an aryl group having 6 to 12 carbon atoms, a bisphenol compound represented by the formula (III) wherein R 1 and R 2 each independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 5 to 8 carbon atoms, an alkyl cycloalkyl group having 6 to 12 carbon atoms, an aralkyl group having 7 to 12 carbon atoms or an aryl group having 6 to 12 carbon atoms, and a phosphorus trihalide are reacted. 4. A stabilizer for an organic material, comprising the phosphite compound according to claim 1 . 5. The stabilizer according to claim 4 , wherein the organic material is a thermoplastic resin. 6. The stabilizer according to claim 5 , wherein the thermoplastic resin is a polyolefin or an engineering plastic. 7. A method for stabilizing an organic material, wherein the phosphite compound according to claim 1 is added to an organic material. 8. The method according to claim 7 , wherein the organic material is a thermoplastic resin. 9. The method according to claim 8 , wherein the thermoplastic resin is a polyolefin or an engineering plastic. 10. A stabilized organic material composition comprising an organic material and a phosphite compound according to claim 1 . 11. The composition according to claim 10 , wherein the organic material is a thermoplastic resin. 12. The composition according to claim 11 , wherein the thermoplastic resin is a polyolefin or an engineering plastic.
with hydroxyaryl compounds · CPC title
containing carbon-to-carbon double bonds but no carbon-to-carbon triple bonds · CPC title
Compositions of unspecified macromolecular compounds · CPC title
containing only phosphorus · CPC title
condensed with carbocyclic or heterocyclic rings or ring systems · CPC title
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