Purification and separation techniques for cannabinoids

Patent metadata

Field	Value
Publication number	US-11027218-B2
Application number	US-201716308421-A
Country	US
Kind code	B2
Filing date	Jun 9, 2017
Priority date	Jun 10, 2016
Publication date	Jun 8, 2021
Grant date	Jun 8, 2021

Abstract

This disclosure relates to techniques and methods to isolate and purify cannabinoids, such as CBDV, CBD, CBC, THCV, THC, CBN, CBG, CBDA, THCA, or CBGA. Evaporation and sonicating techniques are used to isolate and purify cannabinoids, such as CBDV, CBD, CBC, THCV, THC, CBN, CBG, CBDA, THCA, or CBGA. The resulting compounds find further use within the devices and compositions described herein as well as for preparative and analytical methods.

First claim

What is claimed is:

1. A method of purifying one or more cannabinoids from a plant material of genus cannabis , comprising:
adding the plant material of genus cannabis to ethanol;
sonicating the ethanol and plant material of genus cannabis at a temperature of between about −80 to 30 degrees Celsius;
dissolving cannabinoids in the ethanol to create a solution of cannabinoids;
physically separating the plant material of genus cannabis from the solution comprising cannabinoids; and
evaporating the ethanol from the solution at a pressure of less than 1 atmosphere.

2. The method of claim 1 , comprising sonicating the ethanol and plant material of genus cannabis at a temperature of between about −50 to 10 degrees Celsius.

3. The method of claim 2 , comprising sonicating the ethanol and plant material of genus cannabis at a temperature of between about −30 to −10 degrees Celsius.

4. The method of claim 1 , comprising evaporating the ethanol from the solution at a temperature of between about 20 to 60 degrees Celsius.

5. The method of claim 1 , comprising collecting a precipitated cannabinoid from within an ethanolic solution of cannabinoids.

6. The method of claim 5 , comprising dissolving the precipitated cannabinoid in an alcohol, creating a second solution, then recrystallizing the precipitated cannabinoid from the second solution.

7. The method of claim 6 , comprising evaporating alcohol from the second solution.

8. The method of claim 6 , wherein the alcohol is ethanol.

Assignees

• Canopy Growth Corp

Inventors

• Levy Kurt Aron
• Enmark Karl

Classifications

• B01D11/0265 Primary

  Applying ultrasound · CPC title

• B01D9/0018

  Evaporation of components of the mixture to be separated · CPC title

• B01D11/0288

  Applications, solvents · CPC title

• B01D9/00

  Crystallisation (crystallisation directly from the vapour phase B01D7/02; making single crystals C30B {; crystallisation as part of the Bayer process also classified in C01F7/14}) · CPC title

• B01D11/02

  of solids · CPC title