Methods of treating hair related conditions

Patent metadata

Field	Value
Publication number	US-9901557-B2
Application number	US-201514969939-A
Country	US
Kind code	B2
Filing date	Dec 15, 2015
Priority date	Feb 16, 2009
Publication date	Feb 27, 2018
Grant date	Feb 27, 2018

Abstract

Disclosed herein are methods for treating hair related disorders, including compounds that may be specific or modulate PPAR receptors.

First claim

What is claimed is:

1. A method for modulating hair growth in a human subject in need thereof, the method comprising administering a therapeutically effective amount to the subject of a composition comprising:
N-acetyl-(S)-3-(4-aminophenyl)-2-methoxypropionic acid, or a pharmaceutically acceptable salt or an N-oxide thereof; and
an excipient.

2. The method of claim 1 , wherein the composition is administered topically.

3. A method for treating hair de-pigmentation or vitiligo in a human subject in need thereof, the method comprising administering a therapeutically effective amount to the subject of a composition comprising:
N-acetyl-(S)-3-(4-aminophenyl)-2-methoxypropionic acid, or a pharmaceutically acceptable salt or an N-oxide thereof; and
an excipient.

4. A method of stimulating hair growth, the method comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising:
N-acetyl-(S)-3-(4-aminophenyl)-2-methoxypropionic acid, or a pharmaceutically acceptable salt or an N-oxide thereof; and
an excipient.

5. The method of claim 4 , wherein the composition is administered topically.

6. The method of claim 4 or 5 , wherein the composition further comprises a hair stimulating agent.

7. The method of claim 4 or 5 , wherein the method further comprises administering a hair stimulating agent.

8. A method for treating or ameliorating limited hair growth, short hair growth, or hair loss in a subject in need thereof, the method comprising administering a therapeutically effective amount to the subject of a composition comprising:
N-acetyl-(S)-3-(4-aminophenyl)-2-methoxypropionic acid, or a pharmaceutically acceptable salt or an N-oxide thereof; and
an excipient.

9. The method of claim 8 , wherein the composition further comprises a hair stimulating agent.

10. The method of claim 8 , wherein the method further comprises administering a hair stimulating agent.

11. The method of claim 8 , wherein the composition is pharmaceutically and/or cosmetically acceptable.

12. The method of claim 1 , wherein the composition further comprises a hair stimulating agent.

13. The method of claim 1 , wherein the method further comprises administering a hair stimulating agent.

14. The method of claim 1 , wherein the composition is pharmaceutically and/or cosmetically acceptable.

15. The method of claim 3 , wherein the composition is administered topically.

16. The method of claim 3 , wherein the composition further comprises a hair stimulating agent.

17. The method of claim 3 , wherein the method further comprises administering a hair stimulating agent.

18. The method of claim 3 , wherein the composition is pharmaceutically and/or cosmetically acceptable.

19. The method of claim 4 , wherein the composition is pharmaceutically and/or cosmetically acceptable.

20. The method of claim 8 , wherein the composition is administered topically.

21. A method for treating or ameliorating alopecia in a subject in need thereof, the method comprising administering a therapeutically effective amount to the subject of a composition comprising:
N-acetyl-(S)-3-(4-aminophenyl)-2-methoxypropionic acid, or a pharmaceutically acceptable salt or an N-oxide thereof; and
an excipient.

22. The method of claim 21 , wherein the alopecia is selected from the group consisting of: anagen alopecia, telogen alopecia, and alopecia areata.

23. The method of claim 21 , wherein the composition further comprises a hair stimulating agent.

24. The method of claim 21 , wherein the method further comprises administering a hair stimulating agent.

25. The method of claim 21 , wherein the composition is pharmaceutically and/or cosmetically acceptable.

26. The method of claim 21 , 23 , 24 , or 25 , wherein the composition is administered topically.

Assignees

• Nogra Pharma Ltd

Inventors

• Baroni Sergio
• Bellinvia Salvatore
• Viti Francesca

Classifications

• A61Q19/008

  Preparations for oily skin · CPC title

• A61P17/10

  Anti-acne agents · CPC title

• A61K8/44

  Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof · CPC title

• A61Q7/00

  Preparations for affecting hair growth · CPC title

• A61K2800/78

  Enzyme modulators, e.g. Enzyme agonists · CPC title