Neprilysin inhibitors
US-9688692-B2 · Jun 27, 2017 · US
US9890127B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9890127-B2 |
| Application number | US-201414775354-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 11, 2014 |
| Priority date | Mar 11, 2013 |
| Publication date | Feb 13, 2018 |
| Grant date | Feb 13, 2018 |
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Disclosed are compounds, such as pyridazinones, that can be, inter alia, used for treating cancer.
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What is claimed is: 1. A compound having a formula of: or a pharmaceutically acceptable salt or ester thereof. 2. A pharmaceutical composition comprising a compound having a formula of: or a pharmaceutically acceptable salt or ester thereof. 3. The compound of claim 1 having a formula of: or a pharmaceutically acceptable salt thereof. 4. The compound of claim 1 having a formula of: or an ester thereof. 5. The pharmaceutical composition of claim 2 , wherein the compound has a formula of: or a pharmaceutically acceptable salt thereof. 6. The pharmaceutical composition of claim 2 , wherein the compound has a formula of: or an ester thereof. 7. The pharmaceutical composition of claim 2 , wherein the compound, or a pharmaceutically acceptable salt thereof, is present in amount of at least 90% optical purity. 8. The pharmaceutical composition of claim 2 , wherein the compound, or a pharmaceutically acceptable salt or ester thereof, is present in amount of at least 95% optical purity. 9. The pharmaceutical composition of claim 2 , wherein the compound, or a pharmaceutically acceptable salt or ester thereof, is present in amount of at least 96% optical purity. 10. The pharmaceutical composition of claim 2 , wherein the compound, or a pharmaceutically acceptable salt or ester thereof, is present in amount of at least 98% optical purity. 11. The pharmaceutical composition of claim 2 , wherein the compound, or a pharmaceutically acceptable salt or ester thereof, is present in amount of at least 99% optical purity. 12. The pharmaceutical composition of claim 2 , wherein the pharmaceutical composition is suitable for oral or parenteral administration.
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