Mechanical agitator with seal housing assembly

Patent metadata

Field	Value
Publication number	US-9880067-B2
Application number	US-201314094925-A
Country	US
Kind code	B2
Filing date	Dec 3, 2013
Priority date	Dec 3, 2013
Publication date	Jan 30, 2018
Grant date	Jan 30, 2018

Abstract

A mechanically driven agitator for use in bioprocessing, including a seal housing providing an integral seal around the agitator shaft is provided. Additionally, a fluid mixing assembly comprising a container and the agitator, as well as a support assembly for supporting the fluid mixing assembly, the support assembly further comprising a mounting assembly for lockably engaging the seal housing, are also provided.

First claim

The invention claimed is:

1. A mechanically driven agitator for use in bioprocessing comprising
(a) a rotatable shaft comprising a cylindrical element having a first end and a second end, the shaft having a vertical rotational axis;
(b) an impeller comprising a hub mounted on the first end of the rotatable shaft, the hub having a horizontal axis perpendicular to the vertical rotational axis of the shaft, and at least two arms extending from the hub;
(c) a seal housing assembly comprising an upper housing portion, and a lower housing portion;
wherein the upper housing portion comprises a shoulder having a shoulder surface and a lower part having an external surface, an upper seal assembly, the upper seal assembly comprising an upper shaft seal and an upper shaft bearing, the upper shaft seal including an upper seal annular opening and the upper shaft bearing including an upper bearing annular opening for receiving the rotatable shaft, wherein the upper shaft bearing is fit onto the shaft; and,
wherein the lower housing portion comprises a lower seal assembly, the seal assembly comprising lower shaft seal and a lower shaft bearing, the lower shaft seal including a lower seal annular opening and the lower shaft bearing including a lower bearing annular opening for receiving the rotatable shaft, wherein the lower shaft bearing is fit onto the shaft, and the second end of the shaft passes through the lower housing portion; the lower housing portion comprising an external surface including threads,
an upper carrier housing located in the upper housing portion, a lower carrier housing located in the lower housing portion, the upper carrier housing comprising the upper shaft seal and the upper shaft bearing, the lower carrier housing comprising the lower shaft seal and the lower shaft bearing, wherein the upper seal assembly and the lower seal assembly each further comprise an anti rotation device, each of the upper and lower carrier housings comprising a carrier housing protrusion formed into each of the upper and lower carrier housings, the anti rotation device comprising a notch in the shaft seal, and the carrier housing protrusion, wherein the protrusion engages with the shaft seal and prevents rotation of the shaft seal;
(d) a locking ring, wherein the locking ring comprises an upper locking ring face and a lower locking ring face and an opening passing through the upper locking ring face and the lower locking ring face, the opening having a surface including threads, wherein the locking ring is threadably engageable with the lower housing portion of the seal housing assembly, and the upper face is suitable for contacting an outer surface of a wall of a bioprocessing container;
(e) a support flange including a flange annular opening for receiving the rotatable shaft, the flange having a flange upper face, and a flange lower face suitable for sealing against an inner surface of the wall of a bioprocessing container; wherein the flange annular opening includes a wall sealably coupled to the external surface of the lower part of the upper housing portion of the seal housing assembly;
wherein the upper face of the flange presses against the surface of the shoulder of the upper housing portion, the lower face of the flange seals against the inner surface of the wall of the bioprocessing container and the upper face of the locking ring contacts the outer surface of the wall of the bioprocessing container when the internal surface of the locking ring is threadably engaged with the external surface of the lower housing portion of the seal housing assembly.

2. The mechanically driven agitator of claim 1 , further comprising seal integrity testing assembly, the assembly comprising an inner channel in the seal housing assembly along the rotatable shaft communicating with the upper and lower seal assemblies, wherein the lower housing portion further comprises a port communicating with the inner channel.

3. The mechanically driven agitator of claim 1 , wherein the upper and lower seal assembly each further comprise at least one resilient ring that compresses when the seal assembly is fitted into the respective housing portion.

4. The mechanically driven agitator of claim 1 , further comprising a coupling fitting attached to the second end of the shaft.

5. The mechanically driven agitator of claim 4 , further comprising a coupler device engageable with the coupling fitting.

6. A mixing assembly, comprising
(a) a bioprocessing container comprising a closed container having an interior volume suitable for containing fluid, the container comprising at least one side wall, a top wall, and a bottom wall, the side wall(s) being joined to the top wall and the bottom wall; and at least an inlet port, and a drain port, wherein the bioprocessing container further comprises:
(b) the mechanically driven agitator of claim 1 , attached to the bottom wall or the top wall.

7. A tote for supporting a mixing assembly, the tote comprising a floor for receiving the mixing assembly, the floor including an opening for receiving a lower housing portion of a seal housing assembly of the mixing assembly, the mixing assembly comprising
(a) a bioprocessing container comprising a closed container having an interior volume suitable for containing fluid, the container comprising at least one side wall, a top wall, and a bottom wall, the side wall(s) being joined to the top wall and the bottom wall; and at least an inlet port, and a drain port, wherein the bioprocessing container further comprises:
(b) a mechanically driven agitator for use in bioprocessing comprising
a rotatable shaft comprising a cylindrical element having a first end and a second end, the shaft having a vertical rotational axis;
an impeller comprising a hub mounted on the first end of the rotatable shaft, the hub having a horizontal axis perpendicular to the vertical rotational axis of the shaft, and at least two arms extending from the hub;
the seal housing assembly comprising an upper housing portion, and the lower housing portion;
wherein the upper housing portion comprises a shoulder having a shoulder surface and a lower part having an external surface, an upper seal assembly, the upper seal assembly comprising an upper shaft seal and an upper shaft bearing, the upper shaft seal including an upper seal annular opening and the upper shaft bearing including an upper bearing annular opening for receiving the rotatable shaft, wherein the upper shaft bearing is fit onto the shaft; and,
wherein the lower housing portion comprises a lower seal assembly, the seal assembly comprising lower shaft seal and a lower shaft bearing, the lower shaft seal including a lower seal annular opening and the lower shaft bearing including a lower bearing annular opening for receiving the rotatable shaft, wherein the lower shaft bearing is fit onto the shaft, and the second end of the shaft passes through the lower housing portion; the lower housing portion comprising an external surface including threads,

an upper carrier housing located in the upper housing portion, a lower carrier housing located in the lower housing portion, the upper carrier housing comprising the upper shaft seal and the upper shaft bearing, the lower carrier housing comprising the lower shaft seal and the lower shaft bearing, wherein the upper seal assembly and the lower seal assembly each further comprise an anti rotation device, each of the upper and lower carrier housings comprising a carrier housing protrusion formed into each of the upper and lower carrier housings, the anti rotation device comprising a notch in the shaft seal, and the carrier housing protrusion, wherein the protrusion engages with the shaft seal and prevents rotation of the shaft seal;
a locking ring, wherein the locking r

Assignees

• Pall Corp

Inventors

• Isailovic Bojan

Classifications

• F16M11/04

  Means for attachment of apparatus; Means allowing adjustment of the apparatus relatively to the stand · CPC title

• F16M11/42

  with arrangement for propelling the support {stands on wheels} · CPC title

• B01F15/0085

  Operations & Transport · mapped topic

• F16C35/045

  with a radial flange to mount the housing · CPC title

• B01F15/00668

  Operations & Transport · mapped topic