Drug delivery device having a cavity sealed by a pressurized membrane

Patent metadata

Field	Value
Publication number	US-9867932-B2
Application number	US-201514928546-A
Country	US
Kind code	B2
Filing date	Oct 30, 2015
Priority date	Oct 30, 2015
Publication date	Jan 16, 2018
Grant date	Jan 16, 2018

Abstract

A digital biomedical device includes a substrate forming a reservoir, a membrane comprising a first layer and a second layer having a strain therebetween, the membrane sealing the reservoir, and a controller configured to activate the membrane and release at least a portion of the strain causing the membrane curl and open the reservoir.

First claim

What is claimed is:

1. A digital biomedical device comprising:
a substrate forming a reservoir;
a membrane comprising a first layer and a second layer having a strain therebetween, the membrane sealing the reservoir;
a controller configured to activate the membrane and release at least a portion of the strain causing the membrane curl and open the reservoir;
a sealing material disposed between the substrate and the membrane; and
a heater element disposed in or adjacent to the sealing material, wherein the heater element is controlled by the controller to break the seal and allow the membrane to be curled by a bending moment caused by the strain difference between the first layer and the second layer of the membrane.

2. The digital biomedical device of claim 1 , wherein the strain difference between the first layer and the second layer of the membrane is greater than about 0.5 percent.

3. A membrane sealing a reservoir of a digital biomedical device, the membrane comprising:
a first layer maintained having a compressive stress; and
a second layer bonded to the first layer and maintained having a tension,
wherein the first layer and the second layer have different lengths in a stress-less state, and wherein the first layer includes a polymer material and the second layer includes a metal material.

4. The membrane of claim 3 , wherein a strain difference between the first layer and the second layer of the membrane is caused by different coefficients of thermal expansion of the first and second layers.

5. The membrane of claim 3 , held in a substantially flat state to be a seal.

6. The membrane of claim 3 , comprising a plurality of doors cut into the membrane around respective reservoirs.

7. A method of manufacturing a digital biomedical device comprising:
providing a substrate including a reservoir;
bonding a stress engineered sealing membrane to the substrate, the stress engineered sealing membrane comprising a first layer and a second layer having a strain therebetween, wherein the stress engineered sealing membrane sealing the reservoir; and
cutting the stress engineered sealing membrane around the reservoir.

8. The method of claim 7 , wherein the strain difference between the first layer and the second layer of the membrane is greater than about 0.5 percent.

9. The method of claim 7 , further comprising providing a controller configured to activate the stress engineered sealing membrane and release at least a portion of the stain, allowing the stress engineered sealing membrane to curl and open the reservoir.

10. The method of claim 9 , further comprising:
providing an adhesive performing the bonding of the stress engineered sealing membrane to the substrate;
providing a heater element disposed adjacent to the adhesive; and
operating the controller to break a bond formed by the adhesive, allowing the stress engineered sealing membrane to curl by a bending moment caused by the strain difference between the first layer and the second layer of the membrane.

11. The method of claim 9 , further comprising:
providing an adhesive performing the bonding of the stress engineered sealing membrane to the substrate;
providing a heater element disposed in the adhesive; and
operating the controller to break a bond formed by the adhesive, allowing the stress engineered sealing membrane to curl by a bending moment caused by the strain difference between the first layer and the second layer of the membrane.

12. The method of claim 7 , wherein the cutting of the stress engineered sealing membrane around the reservoir forms a door having a plurality of sides around the reservoir.

13. The method of claim 7 , wherein the cutting of the stress engineered sealing membrane around the reservoir forms a lid disposed over the reservoir.

Assignees

• IBM

Inventors

• Dang Bing
• Knickerbocker John U
• Maria Joana S B T
• Webb Bucknell C
• Wright Steven L

Classifications

• A61M5/172

  electrical or electronic {(A61M5/16804, A61M5/16831 take precedence)} · CPC title

• A61M2207/00

  Methods of manufacture, assembly or production · CPC title

• A61M5/44

  having means for cooling or heating the devices or media · CPC title

• A61M5/16804 Primary

  Flow controllers · CPC title

• A61M2205/0244

  Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology · CPC title