Preparation of extremely small and uniform sized, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles and MRI T1 contrast agents using the same

Patent metadata

Field	Value
Publication number	US-9861712-B2
Application number	US-201113814036-A
Country	US
Kind code	B2
Filing date	Aug 5, 2011
Priority date	Aug 5, 2010
Publication date	Jan 9, 2018
Grant date	Jan 9, 2018

Abstract

Provided are a preparation method of iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles, iron oxide-based nanoparticles prepared by the same, and a T1 contrast agent including the same. More particularly, the disclosure describes a method for preparation of iron oxide nanoparticles having a extremely small and uniform size of 4 nm or less based on thermal decomposition of iron oleate complex, iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles prepared by the same, and a T1 contrast agent including iron oxide-based paramagnetic or pseudo-paramagnetic nanoparticles.

First claim

The invention claimed is:

1. A method for preparation of iron oxide nanoparticles, comprising:
reacting an iron complex having iron as a central atom and a carboxylate group having 10 to 22 carbon atoms that is bonded to the central atom in a ligand form; a C10 to C22 fatty acid; and a C10 to C22 aliphatic alcohol or C10 to C22 aliphatic amine to prepare iron oxide nanoparticles having an average size of 3.5 nm or less and being paramagnetic or pseudo-paramagnetic at a temperature of 20K or higher, wherein the iron oxide nanoparticle preparation is performed by raising the temperature from room temperature to 200 to 250° C. with a temperature elevation rate of 10° C./m or more, and conducting reaction at 200 to 250° C. for 5 to 60 minutes.

2. The method of claim 1 , further comprising dispersing a precipitate in an organic solvent, wherein the precipitate is obtained by cooling and washing the nanoparticles described above.

3. The method of claim 1 , wherein the iron complex is iron oleate.

4. The method of claim 1 , wherein the fatty acid and aliphatic alcohol are oleic acid and oleyl alcohol, respectively, while the aliphatic amine is oleyl amine.

5. The method of claim 1 , wherein the size of iron oxide is controlled by regulating the molar ratio of fatty acid and aliphatic alcohol or aliphatic amine.

Assignees

• Hyeon Taeg Hwan
• Kim Byung Hyo
• Lee No Hyun
• Kim Eung Gyu
• Jeon Bong Sik
• Kwon Eun Byul
• Park Ju Young
• Myeong Wan Jae
• Hanwha Chemical Corp

Inventors

• Hyeon Taeg Hwan
• Kim Byung Hyo
• Lee No Hyun
• Kim Eung Gyu
• Jeon Bong Sik
• Kwon Eun Byul
• Park Ju Young
• Myeong Wan Jae

Classifications

• A61K49/1842

  the small organic molecule being a phosphate or a phosphonate, not being a phospholipid · CPC title

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title

• Y10T428/2982

  Particulate matter [e.g., sphere, flake, etc.] · CPC title

• Y10S977/882

  Assembling of separate components, e.g. by attaching · CPC title

• A61K49/1836

  the small organic molecule being a carboxylic acid having less than 8 carbon atoms in the main chain · CPC title