High density lipoprotein functionalized magnetic nanostructures
US-2019091154-A1 · Mar 28, 2019 · US
Nanoparticles for magnetic resonance imaging applications
US10086094B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10086094-B2 |
| Application number | US-201514852432-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 11, 2015 |
| Priority date | Sep 15, 2014 |
| Publication date | Oct 2, 2018 |
| Grant date | Oct 2, 2018 |
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- Title
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Abstract
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A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized nanoparticle with a zwitterionic ligand to produce the coated nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic resonance imaging.
First claim
Opening claim text (preview).
What is claimed is: 1. A T1 contrast agent for magnetic resonance imaging or magnetic resonance angiography comprising a nanoparticle, wherein an inorganic core of the nanoparticle has a size of between 2.5 and 4 nm, wherein the nanoparticle has a hydrodynamic diameter of no more than 5 nm, and wherein the nanoparticle is superparamagnetic. 2. The T1 contrast agent of claim 1 , wherein the inorganic core has a size of between 2.5 and 3.5 nm. 3. The T1 contrast agent of claim 1 , wherein a surface of the nanoparticle includes a zwitterionic dopamine sulfonate ligand. 4. The T1 contrast agent of claim 1 , wherein a surface of the nanoparticle includes a DS ligand. 5. The T1 contrast agent of claim 1 , wherein the nanoparticle includes an iron oxide.
Assignees
Inventors
Classifications
- A61K49/1839Primary
the small organic molecule being a lipid, a fatty acid having 8 or more carbon atoms in the main chain, or a phospholipid · CPC title
Coated nanoparticles, e.g. nanoparticles coated with organic surfactant · CPC title
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Frequently asked questions
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- What does patent US10086094B2 cover?
- A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized nanoparticle with a zwitterionic ligand to produce the coated nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic resonance imaging.
- Who is the assignee on this patent?
- Massachusetts Inst Technology
- What technology area does this patent fall under?
- Primary CPC classification A61K49/1839. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 02 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).