Pharmaceutical composition containing extract of houttuynia cordata as active ingredient for preventing and treating dementia, parkinson's disease, or epilepsy

Patent metadata

Field	Value
Publication number	US-9861674-B2
Application number	US-201414249867-A
Country	US
Kind code	B2
Filing date	Apr 10, 2014
Priority date	Oct 12, 2011
Publication date	Jan 9, 2018
Grant date	Jan 9, 2018

Abstract

Pharmaceutical compositions containing an extract of Houttuynia cordata (THUNB) as an active ingredient for preventing and treating dementia, Parkinson's disease, or epilepsy and methods for using the same. Since the extract of Houttuynia cordata or the mixture of the extract of Houttuynia cordata and the extract of Ampelopsis japonica Makino has a cell protection effect and/or a cognition function improved effect in various models including an Amyloid-β induced dementia model, a scopolamine induced dementia model, a 6-hydroxydopamine (6-OHDA) induced Parkinson's disease model, and a Kainic acid induced epilepsy model, the extract of Houttuynia cordata or the mixture of the extract of Houttuynia cordata and the extract of Ampelopsis japonica Makino may be used as the pharmaceutical composition for preventing and treating dementia, Parkinson's disease, or epilepsy and in health foods for preventing and treating dementia, Parkinson's disease, or epilepsy.

First claim

What is claimed is:

1. A method for treating Parkinson's disease or epilepsy comprising injecting an effective amount of an extract of Houttuynia cordata into a subject having Parkinson's disease or epilepsy.

2. A method for treating dementia, Parkinson's disease, or epilepsy comprising injecting effective amounts of an extract of Houttuynia cordata and an extract of Ampelopsis japonica into a subject having dementia, Parkinson's disease, or epilepsy.

3. The method of claim 1 , wherein the extract is extracted by water, a lower alcohol of C 1 to C 2 , or a mixture thereof.

4. The method of claim 3 , wherein the lower alcohol is ethanol or methanol.

5. The method of claim 2 , wherein the extract is extracted by water, a lower alcohol of C 1 to C 2 , or a mixture thereof.

6. The method of claim 5 , wherein the lower alcohol is ethanol or methanol.

7. The method of claim 2 , wherein the mixture of the extract of Houttuynia cordata and the extract of Ampelopsis japonica Makino has a mixed ratio of 1:1 to 10:1.

8. The method of claim 2 , wherein the dementia is any one selected from the group consisting of Alzheimer's disease, vascular dementia, and mild cognitive impairment (MCI).

9. The method of claim 1 , wherein the subject has Parkinson's disease.

10. The method of claim 1 , wherein the subject has epilepsy.

11. The method of claim 2 , wherein the subject has Parkinson's disease.

12. The method of claim 2 , wherein the subject has epilepsy.

13. The method of claim 2 , wherein the subject has dementia.

14. The method of claim 13 wherein the dementia is any one selected from the group consisting of Alzheimer's disease, vascular dementia, and mild cognitive impairment (MCI).

Assignees

• Univ Industry Cooperation Group Kyung Hee Univ
• Univ-Industry Cooperation Group Of Kyung Hee Univ

Inventors

• Oh Myung Sook
• Kim Hyo Geun
• Park Hanbyeol

Classifications

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• A61K36/78 Primary

  Saururaceae (Lizard's-tail family) · CPC title

• A61K36/87

  Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine · CPC title

• A61K2300/00

  Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00 · CPC title