PVAX copolymer and PVAX microparticles comprising the same

Patent metadata

Field	Value
Publication number	US-9844564-B2
Application number	US-201314432114-A
Country	US
Kind code	B2
Filing date	Sep 30, 2013
Priority date	Sep 28, 2012
Publication date	Dec 19, 2017
Grant date	Dec 19, 2017

Abstract

The present invention includes a vanillyl alcohol-containing copolyoxalate copolymer (PVAX). The present invention also includes a PVAX microparticle comprising PVAX. In one aspect, the compositions of the invention can be used as a drug delivery system, an antioxidant or anti-inflammatory composition, a composition for preventing or treating ischemic disease, a composition for inhibiting the side effects of anticancer drugs, a contrast agent, and/or a composition for diagnosing ischemic disease.

First claim

What is claimed:

1. A method of treating or preventing a complication or condition associated with solid organ transplantation in a subject in need thereof, wherein the complication or condition is reperfusion injury, and the method comprises administering to the subject a therapeutically effective amount of a pharmaceutically acceptable composition comprising a microparticle as an active ingredient,
wherein the microparticle comprises a copolymer comprising 2-(4-hydroxymethyl)-2-methoxy-phenoxy)-2-oxoacetic acid (VAOX) as a monomer, and
wherein the copolymer undergoes at least partial degradation to release vanillyl alcohol within the body of the subject.

2. The method of claim 1 , wherein the copolymer further comprises 2-((4-(hydroxymethyl)cyclohexyl)methoxy)-2-oxoacetic acid (CHDOX) as a monomer.

3. The method of claim 2 , wherein the copolymer is represented by Formula (I):

4. The method of claim 3 , wherein in (I) the number of CHDOX monomers is an integer ranging from 10 to 50, and the number of VAOX monomers is an integer ranging from 5 to 30.

5. The method of claim 3 , wherein in (I) the molar ratio of CHDOX to VAOX ranges from about 4:1 to about 2:3.

6. The method of claim 3 , wherein the average molecular weight of (I) is about 10,000-20,000 Dalton.

7. The method of claim 1 , wherein the microparticle has an average diameter ranging from about 200 nm to about 20 μm.

Assignees

• Nat Univ Chonbuk Ind Coop Found
• Beth Israel Deaconess Medical Ct Inc
• Industrial Cooperation Foundation Chonbuk Univ
• Beth Israel Deaconess Medical Ct Inc

Inventors

• Lee Dong Won
• Hong Dong Hyun
• Kang Peter M

Classifications

• A61P35/00

  Antineoplastic agents · CPC title

• C08G83/00

  Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00 · CPC title

• A61K49/0093

  Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle · CPC title

• C08G63/18

  the acids or hydroxy compounds containing carbocyclic rings · CPC title

• C08G63/133

  Hydroxy compounds containing aromatic rings · CPC title