System and method for titrating liquids

Patent metadata

Field	Value
Publication number	US-9835600-B2
Application number	US-201414160029-A
Country	US
Kind code	B2
Filing date	Jan 21, 2014
Priority date	Feb 28, 2006
Publication date	Dec 5, 2017
Grant date	Dec 5, 2017

Abstract

A system for titrating liquids, with a syringe or tip, comprising a holding device and at least one tag and a metering equipment, comprising an additional holding device for holding the syringe or tip on the holding device, a reading device for reading the tag of the syringe or tip held by the additional holding device, a driving device having a motor, which is detachably coupled with a plunger of the syringe when the same is held by the additional holding device, or which is coupled with a plunger which is arranged in a cylinder which is coupled with the tip via a fluid conduit, when the same is held by the additional holding device, an operating device for operating the metering equipment and a control device, connected with the operating device, the reading device and the driving device, which controls the movement of the plunger depending of the tag of the inserted syringe or tip.

First claim

What is claimed is:

1. A system for titrating liquids, the system comprising:
a syringe ( 1 ) comprising a plunger ( 9 ) and a holding device;
a metering equipment ( 13 ) comprising:
an additional holding device for holding the syringe ( 1 ) on the holding device;
a driving device ( 18 ) having a motor ( 19 ), which is detachably coupled with the plunger ( 9 ) of the syringe ( 1 ) when the same is held by the additional holding device;
an operating device ( 23 ) for operating the metering equipment ( 13 ); and
a control device ( 22 ), connected with the operating device ( 23 ) and the driving device ( 18 ), configured to:
control a movement of the plunger ( 9 ) for the delivery of at least one first amount of liquid in a first delivery phase,
wherein the control device is further configured to control the movement of the plunger in the first delivery phase when an operating element of the operating device is actuated, and
configured to control the movement of the plunger ( 9 ) for the delivery of at least one defined second amount of liquid in a second delivery phase when triggered by an actuation of the operating device ( 23 ) or by reaching the end of the first delivery phase, wherein the at least one defined second amount of liquid is less than the first amount of liquid,
at least one tag ( 6 , 7 ) disposed on a flange ( 5 ) of the syringe ( 1 ), wherein the metering equipment ( 13 ) further comprises a reading device ( 17 ) for reading the tag ( 6 , 7 ) of the syringe ( 1 )
wherein the tag ( 6 , 7 ) is configured to indicate the nominal volume of the syringe ( 1 ),
wherein the control device ( 22 ) is configured to control the movement of the plunger ( 9 ), the speed and/or acceleration of the plunger ( 9 ) and/or the displacement of the plunger ( 9 ) depending on the tag of the syringe ( 1 ),
wherein the control device is configured to control a speed and/or an acceleration of the plunger ( 9 ) such that the speed, and/or the acceleration of the plunger of a syringe with a first volume is less than the speed, and/or the acceleration of the plunger of a syringe with a second volume less than the first volume or
wherein the control device ( 22 ) is configured to control a speed and/or an acceleration of the plunger ( 9 ) such that the speed, the acceleration of a syringe with a first volume is greater than the speed, and/or the acceleration of the plunger of a syringe with a second volume less than the first volume.

2. The system according to claim 1 , wherein the tag ( 6 , 7 ) is read mechanically and/or optically by the reading device.

3. The system according to claim 1 , wherein the control device ( 22 ) is configured to control the delivery of small defined amounts of liquid having a volume smaller than 1/100 of the nominal volume of the syringe ( 1 ).

4. The system according to claim 3 , wherein the control device ( 22 ) is configured to control the delivery of small defined amounts of liquid having a volume smaller than 1/500 of the nominal volume of the syringe ( 1 ).

5. The system according to claim 4 , wherein the control device ( 22 ) is configured to control the delivery of small defined amounts of liquid having a volume in the region of about one or several thousandths of the nominal volume of the syringe ( 1 ).

6. The system according to claim 1 , wherein the control device ( 22 ) is configured to control the delivery of the second amount of liquid in the form of droplets.

7. The system according to claim 1 , wherein the control device ( 22 ) is configured to control the delivery of the second amount of liquid in a free jet or in the form of ejected droplets.

8. The system according to claim 1 , wherein the control device ( 22 ) is configured to control the delivery of the second amount of liquid in the form of a running off flow or running off droplets.

9. The system according to claim 1 , wherein the control device ( 22 ) is configured to control a movement of the plunger ( 9 ) only for a predetermined number of actuations of the operating element, and is configured to initiate the second delivery phase.

10. The system according to claim 1 , wherein the control device ( 22 ) is configured to initiate the second delivery phase upon the actuation of the operating device, wherein the actuation is a pre-defined actuation.

11. The system according to claim 1 , further comprising a sensor which aims at a volume to which a delivery opening of the syringe ( 1 ) is directed when it is held by the additional holding device on the metering equipment ( 13 ), in order to detect an approach to the apex point of the titration, and the control device ( 22 ) being configured to reduce the speed of the plunger ( 9 ) and/or initiate the second delivery phase when approaching the apex point of the titration in the first delivery phase, wherein the control device is connected to the sensor.

12. The system according to claim 2 , wherein the holding device comprises the flange ( 5 ) on a cylindrical or sleeve-shaped body of the syringe ( 1 ) and/or a collar at the end of the plunger ( 9 ) of the syringe ( 1 ).

13. The system according to claim 2 , wherein the driving device ( 18 ) comprises an electric motor ( 19 ).

14. The system according to claim 13 , wherein the electric motor ( 19 ) is a DC motor.

15. The system according to claim 2 , wherein the control device ( 22 ) is configured to establish the amount of liquid that has been delivered by summing the amount of liquid delivered in the first delivery phase and the second delivery phase.

16. The system according to claim 2 , further comprising an increment transmitter and a sensor, wherein the driving device ( 18 ) and/or the plunger ( 9 ) is coupled with the increment transmitter for detecting the position of the plunger ( 9 ), and the control device ( 22 ) is coupled with the sensor for sensing the increment transmitter.

17. The system according to claim 2 , wherein the operating device ( 23 ) comprises at least one electric push-button ( 23 . 2 ) and/or an electric switch.

18. The system according to claim 2 , wherein the control device ( 22 ) is an electric control device.

19. The system according to claim 18 , wherein the control device is program driven.

20. The system according to claim 1 wherein the control device is further configured to reduce the speed of the plunger with respect to its speed at the preceding actuation at every subsequent actuation of the operating element.

21. The system according to claim 18 wherein the control device is configured to increase the speed of the plunger with respect to its speed at the proceeding delivery of a first amount of liquid at the delivery of the second amount of liquid.

22. The system according to claim 18 wherein the control device is configured to increase the speed of the plunger to its maximum speed at the delivery of the second amount of liquid.

Assignees

• Eppendorf Ag

Inventors

• Köhn Heinz-Gerhard
• Andres Karl-Friedrich

Classifications

• Y10T436/2575

  Volumetric liquid transfer · CPC title

• B01L2200/143

  Quality control, feedback systems · CPC title

• B01L3/0227

  Details of motor drive means (B01L3/0231, B01L3/0234 take precedence) · CPC title

• B01L2200/023

  adapted for different sizes of tubes, tips or container · CPC title

• G01N31/16 Primary

  using titration · CPC title