Fully implantable direct cardiac and aortic compression device

Patent metadata

Field	Value
Publication number	US-9833551-B2
Application number	US-201615140058-A
Country	US
Kind code	B2
Filing date	Apr 27, 2016
Priority date	Apr 29, 2015
Publication date	Dec 5, 2017
Grant date	Dec 5, 2017

Abstract

The present invention provides a combined direct cardiac compression and aortic counterpulsation device comprising: an inflatable direct cardiac compression jacket configured when inflated to directly compress a heart and assist in displacing blood therefrom, an aortic counterpulsation chamber configured when inflated to displace aortic volume for the purposes of causing a counterpulsation effect, and a driver operably connected to said inflatable direct cardiac compression jacket and to said aortic counterpulsation chamber, said driver is configured to inflate said direct cardiac compression jacket and to deflate said aortic counterpulsation chamber during systole of the heart; said driver is further configured to deflate said direct cardiac compression jacket and to inflate said aortic counterpulsation chamber during diastole of the heart.

First claim

What is claimed is:

1. A combined direct cardiac compression and aortic counterpulsation device comprising:
an inflatable direct cardiac compression jacket configured when inflated to directly compress a heart and assist in displacing blood therefrom, wherein the inflatable direct cardiac compression jacket comprises an inner membrane attached to an outer member and contoured to surround a heart to compresses the heart during contraction without inverting or significantly perturbing the curvatures of the heart and a fluid between the outer member and the inner membrane, wherein and the device exerts a non-curvature-inverting contraction stain pattern when used on a heart, when the fluid is pressurized;
an aortic counterpulsation chamber configured when inflated to displace aortic volume for the purposes of causing a counterpulsation effect, and
a driver operably connected to said inflatable direct cardiac compression jacket and to said aortic counterpulsation chamber, said driver is configured to move the fluid to inflate said direct cardiac compression jacket and to deflate said aortic counterpulsation chamber during systole of the heart; said driver is further configured to deflate said direct cardiac compression jacket and to inflate said aortic counterpulsation chamber during diastole of the heart.

2. A combined direct cardiac compression and aortic counterpulsation device comprising:
an inflatable direct cardiac compression jacket configured when inflated to directly compress an external surface of a heart and assist in displacing blood therefrom,
an aortic counterpulsation chamber configured when inflated to displace aortic volume for the purposes of causing a counterpulsation effect, and
a driver operably connected to said inflatable direct cardiac compression jacket and to said aortic counterpulsation chamber, said driver is configured to shuttle a drive fluid back and forth between said direct cardiac compression jacket and said aortic counterpulsation chamber to alternate inflations and deflations thereof.

3. A combined direct pulsation and counterpulsation device comprising:
a first inflatable component in direct contact with a heart,
a second inflatable component in direct contact with at least one great artery,
a driver operably connected to said first and second inflatable components, wherein said device is configured to fill said first inflatable component with fluid at least partially removed from said second inflatable component during systolic ejection by the heart; said device is further configured to fill said second inflatable component with fluid at least partially removed from said first inflatable component during diastolic filling of the heart.

4. A combined direct cardiac compression and aortic counterpulsation device comprising:
an inflatable direct cardiac compression device comprising
a resilient inner panel in contact with a heart periphery comprising one or membranes contoured to provide curvatures generally in the shape of the heart to supply resistance to the movement of the heart to affect the end-diastolic heart volume,
an inflatable outer panel comprising one or more inflatable membranes positioned at least partially around the resilient inner panel to inflate and provide resistance to the movement of the heart to affect the end-systolic heart volume without inverting or significantly perturbing the curvatures of the heart, and one or more fluid connections in communication with the inflatable outer panel for inflation and deflation;
an aortic counterpulsation device, wherein the aortic counterpulsation device comprises a shell comprising an outer surface and a substantially concave inner surface, a flexible membrane coupled to the shell to form an inflatable space therebetween, wherein the flexible membrane has a deflated configuration and an inflated configuration, an inlet/outlet port in fluid communication with the inflatable space, and coupled to the shell to removeably position to hold the flexible membrane against a radially outer side of a curvature of the aorta; and
a driver operably connected to the one or more fluid connections of the inflatable direct cardiac compression device and to the aortic counterpulsation device to inflate the inflatable direct cardiac compression device and to deflate the aortic counterpulsation device during systole of the heart and to deflate the inflatable direct cardiac compression device and to inflate the aortic counterpulsation device during diastole of the heart.

5. The device of claim 4 , wherein the aortic counterpulsation device comprises a wrap around the shell for holding the device against the ascending aorta, wherein the shell is configured to extend around only a portion of the circumference of the ascending aorta.

6. The device of claim 4 , wherein the shell is a substantially inelastic curved shell.

7. The device of claim 4 , wherein the flexible membrane is substantially inelastic.

8. The device of claim 4 , wherein a fluid is disposed within the inflatable space in the inflated configuration.

9. The device of claim 4 , wherein the concave inner surface forms a smooth curved ovate projection configured to cause the outer side of the curvature of the aorta to flex into a conic shape.

10. The device of claim 4 , wherein the concave inner surface forms a smooth curved ovate projection configured to cause the outer side of the curvature of the aorta to flex substantially without stretching a wall of the aorta.

11. The device of claim 4 , wherein the inflatable direct cardiac compression device comprises eight at least partially overlapped membranes connected to form a continuous outer edge.

12. The device of claim 4 , wherein the resilient inner panel, the inflatable outer panel or both comprise an elastomeric polyurethane, a latex, a polyetherurethane, a polycarbonateurethane, a silicone, a polysiloxaneurethane, a hydrogenated polystyrene-butadiene copolymer, an ethylene-propylene, a dicyclopentadiene terpolymer, hydrogenated poly(styrene- butadiene) copolymer, a poly(tetramethylene-ether glycol) urethanes, a poly(hexamethylenecarbonate-ethylenecarbonate glycol) urethanes or combinations thereof.

13. The device of claim 4 , further comprising one or more resilient members comprise individually a metal, an alloy, a memory metal, a composite, a polymer, a plastic, a memory plastic, strands, yarns, strips, or a combination thereof.

14. The device of claim 4 , further comprising one or more sensors, one or more electrodes to provide pacing stimuli to the heart, one or more electrodes to provide an electrical shock to the heart for defibrillation, one or more electrodes to provide an electrical stimuli to the heart, or a combination thereof in contact with the direct compression cardiac device.

15. The device of claim 4 , further comprising one or more bioactive agents selected from antimicrobials, antibiotics, antimitotics, antiproliferatives, antisecretory agents, non-steroidal anti-inflammatory drugs, immunosuppressive agents, antipolymerases, antiviral agents, antibody targeted therapy agents, prodrugs, free radical scavengers, antioxidants, biologic agents or combinations thereof.

16. The device of claim 4 , wherein the driver is an electric driver.

17. The device of claim 4 , wherein the inflatable direct cardiac compression device comprises an inner membrane attached to an outer member and contoured to surround a heart to compresses the heart during contraction without inverting or significantly perturbing the curvatures of the heart and a fluid between the outer member and the inner mem

Assignees

• Texas A & M Univ Sys
• Corinnova Incorporated

Inventors

• Criscione John C
• Leschinsky Boris

Classifications

• A61N1/3962

  in combination with another heart therapy · CPC title

• A61M2205/054

  with electrotherapy · CPC title

• A61B5/6876

  Blood vessel · CPC title

• A61B5/686

  Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence) · CPC title

• A61B5/6869

  Heart · CPC title